Mesoporous  MgO  microstructures  were  synthesized  using magnesium  acetate  tetrahydrate,  ammonium  oxalate  monohydrate and  Pluronic  F127  via  heating  at  40  °C  for  24  h  and  subsequent calcination. The mesoporous structure of magnesium oxide with the specific  surface  area  of  47m2 /g,  pore  volume  0.30  cm3 /g  and  the average pore size 24 nm is produced. According to ...

BACKGROUND Most conventional methods for delivering chemotherapeutic agents fail to achieve therapeutic concentrations of drugs, despite reaching toxic systemic levels. Novel controlled drug delivery systems are designed to deliver drugs at predetermined rates for predefined periods at the target organ and overcome the shortcomings of conventional drug formulations therefore could diminish the ...

Carvedilol (CAR) is a potent antihypertensive drug but has poor oral bioavailability (24%). A nanosuspension suitable for pulmonary delivery to enhance bioavailability and bypass first-pass metabolism of CAR could be advantageous. Accordingly, the aim of this work was to prepare CAR nanosuspensions and to use artificial neural networks associated with genetic algorithm to model and optimize the...

There is a growing interest in using hydrogels for biomedical applications, because of more favourable characteristics. Some of these hydrogels can be activated by using particular stimuli, for example electrical fields. These stimuli can change the hydrogel shape in a predefined way. It could make them capable of adaptation to patient-specific anatomy even post-implantation. This is the first ...

In modern times, protein drugs have had an ever-increasing ability to efficiently combat disease in the human body, and delivery of polypeptide agents, whether insulin or interferons, to biological targets has thus become a task of great importance to doctors and patients alike. For this reason, it is the goal of many medical researchers to preserve the bioactivity of specific protein drugs and...

Bigels are unique two-phase systems that have recently been presented as a structured method for active ingredient application. The purposes of the current study were to develop and characterize bigel formulations containing loxoprofen. They benefits both hydrogel organo-gel. In order enhance penetration, pluronic lecithin was added form organo-gel, HPMC hydrogel, which properly hydrates stratu...