PURPOSE To determine rate of change over time on scanning laser ophthalmoscopy, HRT, compared to perimetry, and to determine incidence, parametric changes, and risk factors for progression in primary open angle glaucoma (POAG) and chronic primary angle closure angle glaucoma (CPACG) eyes. METHODS Prospective clinical study of 116 POAG eyes and 129 CPACG eyes of different severities of glaucom...

This study investigated whether migraine influences the risk of primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG) in Taiwan.We retrieved the data analyzed in this study from the National Health Insurance Research Database in Taiwan. We included 17,606 newly diagnosed migraine patients without preexisting glaucoma and randomly selected and matched 70,423 subjects witho...

PURPOSE Several studies suggest that vascular dysregulation play a role in the etiology of glaucoma. In the present study, we aimed to investigate the association of endothelial nitric oxide synthase (eNOS) gene polymorphisms with primary open angle glaucoma (POAG) and primary closed angle glaucoma (PCAG). METHODS There were 102 POAG and 88 PCAG patients, diagnosed on the basis of clinical hi...

MYOC encodes a secretary glycoprotein of 504 amino acids named myocilin. MYOC is the first gene to be linked to juvenile open-angle glaucoma (JOAG) and some forms of adult-onset primary open-angle glaucoma (POAG). The gene was identified as an up-regulated molecule in cultured trabecular meshwork (TM) cells after treatment with dexamethasone and was originally referred to as trabecular meshwork...

MMP (Matrix metalloproteinase) 9 is reported to affect glaucoma pathogenesis by altering intraocular pressure (IOP) through its role in remodeling the extracellular matrix (ECM) in the trabecular meshwork. A genetic variant at the promoter region in the MMP9 gene (-1562C>T) has a putative role in regulating its transcription rate and hence can affect genetic predisposition to primary glaucoma. ...

Purpose Agonistic ? 2-adrenergic receptor autoantibodies ( 2-agAAbs) were recently observed in sera of patients with ocular hypertension (OHT), primary (POAG), and secondary open-angle glaucoma (SOAG), yet not healthy controls (HCs). It was the aim present study to investigate presence 2-agAAb aqueous humor (AH) samples OAG correlate these corresponding serum data. Material Methods Thirty-nine ...

AIM To estimate the predicted prevalence of primary open angle glaucoma (POAG) from the activity of a local ophthalmology department. METHOD Using clinic audit data, the local incidence and prevalence of POAG in the registered population of two primary care trusts were calculated. RESULTS The local derived prevalence estimate for POAG was 978 per 100 000 people aged 40-89 years (95% CI 753 ...

PURPOSE To evaluate ocular blood flow velocity indices in untreated primary open-angle glaucoma (POAG) and normal pressure glaucoma (NPG). METHODS Twenty-five untreated patients with NPG, 23 untreated patients with POAG, and 26 age-matched normal control subjects underwent color Doppler imaging for the measurement of blood flow velocity in the central retinal and ophthalmic arteries. Neither ...

Purpose Assessment and a direct comparison of retinal vessel density with the thickness inner layer (IRL) outer (ORL) in same regions macula subjects Alzheimer’s disease (AD) primary open-angle glaucoma (POAG). Methods We analyzed data from 48 eyes healthy control (HC) participants, 71 POAG, 49 AD patients. Ophthalmic examination included optical coherence tomography (OCT) imaging to measure IR...

BACKGROUND The Ocular Hypertension Treatment Study (OHTS) has shown that topical ocular hypotensive medication is effective in delaying or preventing the onset of primary open-angle glaucoma (POAG) in individuals with elevated intraocular pressure (ocular hypertension) and no evidence of glaucomatous damage. OBJECTIVE To describe baseline demographic and clinical factors that predict which pa...