Chronic wounds affect millions of patients worldwide, and it is estimated that this number will increase steadily in the future due to population ageing. The research new therapeutic approaches wound healing includes development nanofibrous meshes use platelet lysate (PL) stimulate skin regeneration. This study considers a combination degradable electrospun blend poly(L-lactide-co-ε-caprolacton...

Makespan scheduling on identical machines is one of the most basic and fundamental packing problem studied in the discrete optimization literature. It asks for an assignment of n jobs to a set of m identical machines that minimizes the makespan. The problem is strongly NPhard, and thus we do not expect a (1 + ε)-approximation algorithm with a running time that depends polynomially on 1/ε. Furth...

Kernelization is a strong and widely-applied technique in parameterized complexity. In a nutshell, a kernelization algorithm for a parameterized problem transforms a given instance of the problem into an equivalent instance whose size depends solely on the parameter. Recent years have seen major advances in the study of both upper and lower bound techniques for kernelization, and by now this ar...

The experimental design problem concerns the selection of k points from a potentially large design pool of p-dimensional vectors, so as to maximize the statistical efficiency regressed on the selected k design points. Statistical efficiency is measured by optimality criteria, including A(verage), D(eterminant), T(race), E(igen), V(ariance) and G-optimality. Except for the Toptimality, exact opt...

The Johnson-Lindenstrauss lemma is a fundamental result in probability with several applications in the design and analysis of algorithms in high dimensional geometry. Most known constructions of linear embeddings that satisfy the Johnson-Lindenstrauss property involve randomness. We address the question of explicitly constructing such embedding families and provide a construction with an almos...

The present work describes the development and the evaluation of cryogel-poly-ε-caprolactone combinatory scaffolds for bone tissue engineering. Gelatin was selected as cell-interactive biopolymer to enable the adhesion and the proliferation of mouse calvaria pre-osteoblasts while poly-ε-caprolactone was applied for its mechanical strength required for the envisaged application. In order to real...

Thermo-responsive diblock copolymers composed of hydrophilic methoxy poly(ethylene glycol) (MPEG) and hydrophobic biodegradable polyesters were prepared for application as injectable drug delivery systems, because they show a thermo-responsive sol-to-gel transition, especially around body temperature, when dispersed in aqueous solutions. The thermogelling hydrogels formed by hydrophobic aggrega...