3D printing is a popular fabrication technique because of its ability to produce complex architectures. Melt-based widely used for thermoplastic polymers like poly(caprolactone) (PCL), poly(lactic acid) (PLA), and poly(lactic-co-glycolic (PLGA) their low processing temperatures. However, traditional melt-based techniques require temperatures pressures high enough achieve continuous flow, limiti...

Submit Manuscript | http://medcraveonline.com Abbreviations: AD: Alzheimer Disease; Apo-E: ApoLipoprotein-E; BBB: Blood Brain Barrier; Brainpeps: BBB Peptide Database; CNS: Central Nervous System; CSF: CerebroSpinal Fluid; EPIC: Engineered Peptide Compound; HAD: HIVAssociated Dementia; HIFU: High Intensity Focused Ultrasound; HIV: HIV Encephalitis; HIV: Human Immunodeficiency Virus; LPR: Lipopr...

Poly(lactic-co-glycolic acid) (PLGA) and/or poly(lactic-acid) (PLA) microspheres are important drug delivery systems. This study investigated eye biocompatibility and safety of PLGA/PLA microspheres through intravitreal injection in rabbits. Normal New Zealand rabbits were randomly selected and received intravitreal administration of different doses (low, medium, or high) of PLGA/PLA microspher...

In the past few years, an increasing number of in situ-forming systems have been reported in the literature for various biomedical applications, including drug delivery, cell encapsulation, and tissue repair. There are several possible mechanisms that lead to in situ gel formation: solvent exchange, UV-irradiation, ionic cross-linkage, pH change, and temperature modulation. The thermosensitive ...

The mechanical properties of a tissue engineering scaffold are particularly important when engineering soft tissues as it has been shown that mechanical stimulation during in vitro tissue development can modulate cell differentiation, increase extracellular matrix synthesis, and enhance the mechanical properties of cartilaginous, ligamentous, and smooth muscle containing tissues [1-5]. Unfortun...

A variety of ocular drug delivery systems, including a controlled release of the drug, drug targeting, and penetration enhancement of the drug, have been investigated. Biodegradable polymers have been widely used as the drug carrier for controlled-release systems. Biodegradable polymers release the drug as they themselves degrade and are finally absorbed within the body. Several ocular drug del...

Abstract Electrospun fibrous scaffolds capable of providing dual growth factor delivery in a controlled manner have distinctive advantages for tissue engineering. In this study, we investigated the formation, structure, and characteristics/properties bicomponent glial cell line-derived neurotrophic (GDNF) nerve (NGF) peripheral regeneration. GDNF NGF were incorporated into core-shell structured...

Nanopartikel poly (lactic-co-glycolic acid) (PLGA) adalah salah satu nanopartikel polimer biodegradable yang paling efektif dalam sistem penghantaran obat. Penelitian ini dilakukan untuk mengkaji perkembangan penelitian PLGA obat melalui pendekatan bibliometrik dengan analisis pemetaan menggunakan VOSviewer. Data artikel diperoleh dari database Google Scholar software Publish or Perish. Kata ku...