The synthesis of a series of chiral PAMAM dendrimers and the formation of chiral dendrimer encapsulated metal nanoparticles are described.

Dendrimers are routinely synthesized as tuneable nanostructures that may be designed and regulated as a function of their size, shape, surface chemistry and interior void space. They are obtained with structural control approaching that of traditional biomacromolecules such as DNA/RNA or proteins and are distinguished by their precise nanoscale scaffolding and nanocontainer properties. As such,...

For successful development of cell-based therapy, both the disposition and differentiation of transplanted cells are directly related to therapeutic effects. In vivo imaging is an attractive tool to obtain real-time information on the disposition of target cells. In various types of imaging methods such as positron emission tomography(PET) and magnetic resonance imaging(MRI), fluorescence imagi...

A human 3D inflammatory cartilage-on-a chip model was develop as a drug screening platform to evaluate the therapeutic efficacy of anti-TNF? mAb-CS/PAMAM dendrimer NPs loaded-Tyramine-Gellan Gum Hydrogel.

Atomistic molecular dynamics simulations have been carried out to reveal the characteristic features of ethylenediamine (EDA) cored protonated (corresponding to neutral pH) poly amido amine (PAMAM) dendrimers of generation 3 (G3) and 4 (G4) that are functionalized with single stranded DNAs (ssDNAs). The four ssDNA strands that are attached via alkythiolate [-S (CH2)6-] linker molecule to the fr...

Synthetic polymers of a specific shape and size play major role in drug delivery systems. Dendrimers are unique synthetic macromolecules of nanometer dimensions with a highly branched structure and globular shape with potential applications in gene and drug delivery. We examine the interaction of several dendrimers of different compositions mPEG-PAMAM (G3), mPEG-PAMAM (G4) and PAMAM (G4) with h...

Carbon dots (CDs) and G4-G6 (polyamidoamine)PAMAM-NH2 dendrimers were self-assembled to produce CDs@PAMAM nanohybrids for transfection bioimaging purposes. CDs synthesized by the hydrothermal method, using ascorbic acid as a starting precursor characterized transmission electron microscopy, UV–Vis, fluorescence (in solution solid-state) techniques. electrostatically combined with PAMAM at room ...

Understanding the structure of hybrid nanoparticle-lipid multilayers is fundamental importance to their bioanalytical applications and nanotoxicity, where nanoparticle-membrane interactions play an important role. Poly(amidoamine) (PAMAM) dendrimers are branched polymeric nanoparticles with potential biomedical due precise tunability physicochemical properties. Here, effect PAMAM (2.9–4.5 nm) e...

We report our single-molecule fluorescence microscopy and molecular dynamics simulation studies on the interaction of poly(amidoamine) dendrimer and squalane hydrocarbon in aqueous solution. Our spectrophotometry measurements indicate that this interaction increases with the pH of the solvent. Our simulations show that squalane resides primarily on the perimeter of the dendrimer at low to neutr...

Purpose: To develop transdermal patches of meloxicam (MLX) using chitosan and hydroxypropyl methylcellulose (HPMC) and polyvinyl alcohol (PVA) as hydrophilic polymers, polyamido amine (PAMAM) dendrimer as a permeation enhancer, and dibutyl pthalate as a plasticizer Methods: The patches were prepared by solvent casting evaporation technique using 3-factor, 3-level Box-Behnken design. The patches...