we describe a 16 year old boy with acne fulminans associated with axial and peripheral polyarthritis. the patient's clinical course and therapy with isotretinoin, prednisolone and oxytetracycline are described. a possible association between the presence of hla -b 27 antigen and reactive arthritis with acne fulminans in this case is evaluated. a review of the literature is included.

Rarely rheumatological features may dominate and is the cause of missed or delayed diagnosis of a malignant lesion. A case is presented wherein the patient with embryonal type of testicular tumour masqueraded with symmetrical polyarthritis with small joint involvement. p53 antigen was detected in testicular tissue. Such an example is indeed unreported in literature to the best of our knowledge.

BACKGROUND Severe extra-articular disease is associated with high levels of rheumatoid factor (RF ) in patients with seropositive rheumatoid arthritis (RA ) and a poor prognosis. It is said that patients with seronegative rheumatoid arthritis have a more benign course and less destructive disease. We observed several patients with seronegative non-rheumatoid polyarthritis, with aggressive extra...