objective(s): in this research, zeolite x and zeolite y were used as vehicle to prepare intestine targeted oral delivery systems of indomethacin and ibuprofen. materials and methods: a soaking procedure was implemented to encapsulate indomethacin or ibuprofen within synthetic zeolites. gravimetric methods and ir spectra of prepared formulations were used to assess drug loading efficiencies into...

Biodegradable polymeric materials are ideal carrier systems for biomedical applications. Features like controlled and sustained delivery, improved drug pharmacokinetics, reduced side effects and safe degradation make the use of these materials very attractive in a lot of medical fields, with dermatology included. A number of studies have shown that particle-based formulations can improve the sk...

Boronic acid-containing (co)polymers have fascinated researchers for decades, garnering attention for their unique responsiveness toward 1,2- and 1,3-diols, including saccharides and nucleotides. The applications of materials that exert this property are manifold including sensing, but also self-regulated drug delivery systems through responsive membranes or micelles. In this review, some of th...

Oral drug delivery route is the most preferable route of drug delivery. It is due to various advantages of this route like ease of administration, patient compliance and flexibility in the formulations. Oral dosage form has really progressed from immediate release to site-specific delivery. The recent scientific and patented literature concluded that an increased interest in novel dosage forms ...

The use of nanotechnology has significantly increased in different fields of science, including the development of drug delivery systems. Currently, the most modern pharmaceutical nanocarriers, such as liposomes, micelles, nanoemulsions and polymeric nanoparticles, demonstrate extremely useful properties from the point of view of drug therapy. In this context, the development of nanocarriers fo...

Particulate systems in the form of liposomes, polymeric micelles, polymeric nano- and microparticles, and many others offer a rational approach for selective delivery of therapeutic agents to the macrophage from different physiological portals of entry. Particulate targeting of macrophages and intracellular drug release processes can be optimized through modifications of the drug carrier physic...

Aim of this work was to compare the efficacy of two loading methods of proteins onto polymeric nanocarriers: adsorption and encapsulation methods. Preliminary studies of protein loading were done using Bovine Serum Albumin (BSA) as model protein. Nanocarriers were prepared starting from polylactic co-glycolic acid (PLGA) polymer; production methods used are two different variants of emulsion ev...

A BST R A C T A drug delivery system can be defined as a system that capable of releasing a carried bioactive agents in a specific location within the body at a specific rate. Anticancer drugs can be associated with colloidal carrier systems such as polymeric micelles, nanocapsules, liposomes and solid lipid nanoparticles, which can be actively targeted to specific tumor cell. The treatment of ...

The therapeutics of tumor is largely confined upon directly encountering the tumor cells. The current cytostatic agents mainly interfere with processes involved in cell growth while the aim in immunotherapy is to make immune effector cells to selectively attack the tumor cells. A recent approach to fight tumor is to impede and interfere with its blood supply, i.e., turning off angiogenesis or n...