Acute effects of alcohol on the peripheral nerves of seven patients with diabetic polyneuropathy and 13 healthy subjects were examined neurophysiologically. Ethanol (1 g/kg) caused a slight increase in skin temperature and motor conduction velocity in both groups. Motor distal latencies decreased in the healthy subjects, but increased among polyneuropathic patients after the consumption of alco...

Objective. To investigate the difference between the measurement of vibration sensation without and with socks. Material and Methods. Fifty healthy volunteers (H group) and 19 patients with diabetic polyneuropathy (PNP group) were included. The sites of measurement were the great toe (GT) and medial malleolus (MM). A standard 128 Hz tuning fork was used in the measurements. Results. Mean durati...

Lymphocytes of 29 subjects were assayed for MIF production in response to P2 peripheral nerve protein, crude human peripheral nerve and human central nervous system Al basic myelin protein. Seven were performed in normal control subjects, 12 in Guillain-Barre patients (GB), 5 with other polyneuropathies and 5 in patients with multiple sclerosis (MS). Only GB patients with acute illness produced...

We compared the toe pinch force in men with and without type 2 diabetes mellitus (T2DM). Sixty-eight male T2DM patients and 35 apparently healthy men matched for age, sex, and body mass index (BMI) were enrolled in this cross-sectional study. We compared the toe pinch force between the subjects with and without T2DM, and we evaluated the effect of diabetic polyneuropathy on toe pinch force in t...

Neuropathic pain (NeP) syndromes remain a difficult-to-treat medical entity. Despite a growing number of pharmacological and invasive analgesic therapies the results remain less than optimal because of insufficient analgesic efficacy and/or occurrence of pronounced side effects. Current guidelines propose the use of multimodal and balanced pharmacological therapies, focused on the underlying pa...