Objective Fibrous dysplasia (FD) presents as skeletal lesions in which normal bone is replaced by abnormal fibrous tissue due to mosaic GNAS mutation. McCune-Albright syndrome (MAS) refers to FD combined with skin (café-au-lait) and endocrine manifestations. This study describes the clinical childhood manifestations of polyostotic FD and MAS in a Nordic cohort. Patients and design We retrospe...

Fibrous dysplasia (FD) is a benign skeletal disorder in which abnormally overgrowing bony lesion replaces normal bone. FD can affect one bone (monostotic form) or multiple bones (polyostotic form). The craniofacial bones are involved in about 10% of subjects with monostotic FD. However, its occurrence in the sinonasal tract is very rare. We report a case of monostotic FD developed only in the i...

Recklinghousen in 1891 were not examples of osteitis fibrosa generalisata and hence of hyperaparathyroidism, but were suffering from "polyostotic fibrous dysplasia." The book concludes with an account of Paget's disease, vith an ingenious, if not very satisfactory, attempt to explain its pathological physiology. It, however, has some useful points in treatment, one or two glasses of milk daily ...

Received 7/9/2003; revised 7/23/2003; accepted 8/10/2003. For correspondence or reprints contact: Yeh-You Shen, M.D., Department of Nuclear Medicine, Shin Kong Wu Ho-Su Memorial Hospital. 95 Wen-Chang Road, Shih Lin District, Taipei 111, Taiwan. Tel: (886)2-28332211 ext. 2280, Fax: (886)2-28389489, E-mail: [email protected] A 57-year-old female underwent whole-body F-fluorodeoxyglucose posi...

McCune-Albright syndrome (MAS) is a rare disease defined by the triad of polyostotic fibrous dysplasia of bone, café-au-lait skin spots, and precocious puberty. No available treatment is effective in changing the course of fibrous dysplasia of bone, but symptomatic patients require therapeutic support to reduce bone pain and prevent fractures and deformities. We report the case of a 27-year-old...

McCune-Albright syndrome (MAS) is a rare, heterogenous, clinical condition caused by a rare genetic mutation. The disorder is more common in females and is characterized by a triad of cutaneous, bone and endocrine abnormalities.  We describe a girl patient with MAS having precocious puberty and multiple cafe-au-lait macules and deforming polyostotic fibrous dysplasia of bone. Clinical presentat...

Fibrous dysplasia (FD) is a common benign intramedullary lesion of the skeleton characterized by proliferation of fibro-osseous tissue. It is viewed as a developmental abnormality that is typically seen in adolescents and young adults. The lesion is usually asymptomatic and many times discovered as an incidental finding. Exophytic FD is an extremely rare variant that has to be differentiated fr...