نتایج جستجو برای: pore blocking model

تعداد نتایج: 2178899  

ژورنال: مدیریت سلامت 2020

Introduction: Hospital administrators have always faced the challenge of providing the best possible health services in a resource-limited environment. The patient flow throughout the hospital is affected by lack of the capacities that can lead to bed-blocking among the hospital units. In this research, the patient flow in the hospital is modeled as an open queueing network with blocking. Then,...

Journal: : 2023

Microrheological studies of givpan-based gel-forming solutions in micron-sized pores have shown that contact interaction the fluid–rock formation system leads to structural and mechanical colmatation porous medium, blocking pore channels by elastic-viscous filtrate plugs, which under normal conditions exhibit viscoplastic qualities. It is these processes develop immediately upon with surface, d...

Journal: :The Journal of General Physiology 1991
B D Winegar R Kelly J B Lansman

The blocking actions of Fe2+, Co2+, and Ni2+ on unitary currents carried by Ba2+ through single dihydropyridine-sensitive Ca2+ channels were recorded from cell-attached patches on myotubes from the mouse C2 cell line. Adding millimolar concentrations of blocker to patch electrodes containing 110 mM BaCl2 produced discrete excursions to the closed channel level. The kinetics of blocking and unbl...

ژورنال: علوم آب و خاک 2013

Excess pore water pressure in clay core dams during construction and primary filling reservoir (first impounding) causes initiation and progression of hydraulic fracture. In this research, the instrumentation data during construction and first filling reservoir (first impounding) was analyzed. It measured internal deformations, pore water pressures and total vertical stresses and compared with ...

Journal: :Neuron 1995
Jian Yang Yuh Nung Jan Lily Y Jan

Inwardly rectifying K+ channels conduct more inward than outward current as a result of voltage-dependent block of the channel pore by intracellular Mg2+ and polyamines. We investigated the molecular mechanism and structural determinants of inward rectification and ion permeation in a strongly rectifying channel, IRK1. Block by Mg2+ and polyamines is found not to conform to one-to-one binding, ...

Journal: :The Journal of General Physiology 1998
Albert Cha Francisco Bezanilla

When attached to specific sites near the S4 segment of the nonconducting (W434F) Shaker potassium channel, the fluorescent probe tetramethylrhodamine maleimide undergoes voltage-dependent changes in intensity that correlate with the movement of the voltage sensor (Mannuzzu, L.M., M.M. Moronne, and E.Y. Isacoff. 1996. Science. 271:213-216; Cha, A., and F. Bezanilla. 1997. Neuron. 19:1127-1140). ...

Journal: :The Journal of biological chemistry 2003
Michael Levy Guido C Faas Peter Saggau William J Craigen J David Sweatt

Synaptic mechanisms of plasticity are calcium-dependent processes that are affected by dysfunction of mitochondrial calcium buffering. Recently, we observed that mice deficient in mitochondrial voltage-dependent anion channels, the outer component of the mitochondrial permeability transition pore, have impairments in learning and hippocampal synaptic plasticity, suggesting that the mitochondria...

Journal: :Biophysical journal 2004
Jordi Cohen Klaus Schulten

ClC chloride channels are voltage-gated transmembrane proteins that have been associated with a wide range of regulatory roles in vertebrates. To accomplish their function, they allow small inorganic anions to efficiently pass through, while blocking the passage of all other particles. Understanding the conduction mechanism of ClC has been the subject of many experimental investigations, but un...

Journal: :Fuel 2022

The water-gas relative permeability is an important parameter to characterize multiphase flow in sediments. To study the of hydrate-bearing porous media, simulations were carried out at pore scale using lattice Boltzmann method. effects hydrate saturation and hydrate-growth habits on permeability, which scaled by considering only, evaluated a two-dimensional medium. Results show that increase c...

Journal: :Biochemical and biophysical research communications 2010
Rafal M Pielak James J Chou

The M2 protein of influenza A virus forms a proton-selective channel that is required for viral replication. It is the target of the anti-influenza drugs, amantadine and rimantadine. Widespread drug resistant mutants, however, has greatly compromised the effectiveness of these drugs. Here, we report the solution NMR structure of the highly pathogenic, drug resistant mutant V27A. The structure r...

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