نتایج جستجو برای: positive remodeling
تعداد نتایج: 708830 فیلتر نتایج به سال:
BACKGROUND/AIMS Angiotensin II receptor blockers (ARBs) have been proved to be effective in preventing atrial structural and electrical remodelinq in atrial fibrillation (AF). Previous studies have shown that parasympathetic remodeling plays an important role in AF. However, the effects of ARBs on atrial parasympathetic remodeling in AF and the underlying mechanisms are still unknown. METHODS...
OBJECTIVES We evaluated the impact of reference vessel segment plaque burden on lesion remodeling. BACKGROUND Intravascular ultrasound (IVUS) assessment of lesion remodeling compares lesions to reference segments. However, reference segments are rarely disease-free and, therefore, have also undergone remodeling changes. METHODS Pre-intervention IVUS was obtained in 274 patients with right coron...
BACKGROUND Pulmonary arterial hypertension, also known as Ascites syndrome (AS), remains a clinically challenging disease with a large impact on both humans and broiler chickens. Pulmonary arterial remodeling presents a key step in the development of AS. The precise molecular mechanism of pulmonary artery remodeling regulating AS progression remains unclear. METHODOLOGY/PRINCIPAL FINDINGS We ...
Background: The process of wound healing involves integrated events including inflammation, granulation tissue formation, matrix deposition and remodeling. Growth factors play a key role in the process. Among them transforming growth factor-ß1 (TGF-ß1) is known to accelerate tissue repair by promoting the synthesis and deposition of extracellular matrix proteins. However, persistence or overact...
BACKGROUND As right ventricular (RV) remodeling in obesity remains underinvestigated, and the impact of left ventricular (LV) diastolic dysfunction on RV hypertrophy is unknown, we aimed to investigate whether (1) sex-specific patterns of RV remodeling exist in obesity and (2) LV diastolic dysfunction in obesity is related to RV hypertrophy. METHODS AND RESULTS Seven hundred thirty-nine subje...
The TMEM16A protein is an important component of Ca(2+)-dependent Cl(-) channels (CaCCs) in vascular smooth muscle cells. A recent study showed that TMEM16A inhibits angiotensin II-induced proliferation in rat basilar smooth muscle cells. However, whether and how TMEM16A is involved in vascular remodeling characterized by vascular smooth muscle cell proliferation remains largely unclear. In thi...
استخوان زنده تحت اثر نیروهای وارده رفتاری از خود بروز می دهد که این رفتار توسط تئوری نوسازی استخوان (bone remodeling) توجیه می گردد. دراین پروژه ابتداء قسمتهای مختلف ساختار فیزیکی استخوان مورد بررسی قرار گرفته، سپس با معرفی فرآیند مکانیزم نوسازی استخوان و خلاصه ای از پژوهشهای دیگر محققین علی الخصوص مدل ریاضی برای نوسازی سطحی استخوان بررسی شده، آنگاه بااستفاده از روشهای عددی حل این مدل درحالت کل...
We aimed to test the hypothesis that gene silencing of tumor necrosis factor alpha converting enzyme (TACE) may attenuate lesion inflammation and positive vascular remodeling and enhance plaque stability in a rabbit model of atherosclerosis. Lentivirus-mediated TACE shRNA was injected into the abdominal aortic plaques of rabbits which effectively down-regulated TACE expression and activities fr...
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