Polyhedral oligomeric silsesquioxane (POSS), bearing eight 3-chloroammoniumpropyl substituents, was studied as a potential nanocarrier in co-delivery systems with doxorubicin (DOX). The toxicity of doxorubicin and POSS:DOX complexes at four different molar ratios (1:1; 1:2, 1:4, 1:8) towards microvascular endothelial cells (HMEC-1), breast cancer cells (MCF-7), and human cervical cancer endothe...

This study aims at the testing of various low-k insulators deposited at temperatures below approximately 160 C for possible application in temperature-limited copper interconnects (e.g., in plastic electronics). Various polymers were tested such as the well-known poly(methyl methacrylate) (PMMA), a Polyhedral Oligomeric Silsesquioxane (POSS) based copolymer partially fluorinated (POSS-F) and th...

We present the relaxation dynamics of glass-forming glycerol mixed with 1.1 nm sized polyhedral oligomeric silsesquioxane (POSS) molecules using dielectric spectroscopy (DS) and two different neutron scattering (NS) techniques. Both, the reorientational dynamics as measured by DS and the density fluctuations detected by NS reveal a broadening of the α relaxation when POSS molecules are added. M...

We report the synthesis and characterization of a series of multiblock thermoplastic polyurethane hydrogels synthesized with PEG as the soft segment and incorporating an isobutyl-functionalized POSS diol (TMP POSS diol) in the hard segment. The molecular weight of PEG was systematically varied to include 10, 20, and 35 kg/mol, while the molar ratio of POSS diol (as chain extender) to PEG was va...

We report on the linear viscoelastic properties of a family of entangled linear thermoplastic nonpolar hybrid inorganic-organic polymers: random copolymers of polystyrene (PS) and styryl-based polyhedral oligosilsesquioxane (POSS), R7(Si8O12)(C6H4CHdCH2), with R ) isobutyl (iBu). A series of styrene-styryl POSS random copolymers with 0, 6, 15, 30, and 50 wt % iBuPOSS were investigated. WAXS and...

Among the varied and diverse family of drug delivery systems (DDSs), such as polymer–drug conjugates, polymeric micelles, dendrimers and molecular containers, polyhedral oligomeric silsesquioxanes (POSS) occupy a special position within the group of biocompatible drug carriers. The extraordinary recommendation of POSS for such systems derives from their three-dimensional structure, nanoscale si...

Quantum dots (QDs) are fluorescent semiconductor nanocrystals that have the potential for major advancements in the field of nanomedicine through their unique photophysical properties. They can potentially be used as fluorescent probes for various biomedical imaging applications, including cancer localization, detection of micrometastasis, image guided surgery, and targeted drug delivery. Their...

The small-angle neutron scattering (SANS) technique has been used to investigate the structure of dendrimers based on polyhedral oligomeric silsesquioxane (POSS) in solution. Three generations and two distinct terminal groups (either vinyl or polyethylene glycol (PEG) terminal groups) as well as four concentrations for each dendrimer have been measured in deuterated tetrahydrofuran. Two main sc...