OBJECTIVES Pregabalin is used to treat neuropathic pain and has shown analgesic properties in postoperative pain. The aim of this study was to investigate the effectiveness and safety of pregabalin in reducing postoperative pain in patients after septoplasty. METHODS Forty-seven patients scheduled for elective septoplasty were randomly assigned to groups that received either pregabalin (150 m...

UNLABELLED Aims/Introduction:  Diabetic peripheral neuropathy (DPN) is often associated with pain, and thus a new treatment option is anticipated. We recently showed the efficacy of pregabalin in a randomized, double-blind, placebo-controlled, 14-week trial in Japanese patients with painful DPN. In the present study, we evaluated the long-term efficacy and safety of pregabalin for the relief of...

Migraine is characterized by severe headaches that can be preceded by an aura likely caused by cortical spreading depression (SD). The antiepileptic pregabalin (Lyrica) shows clinical promise for migraine therapy, although its efficacy and mechanism of action are unclear. As detected by diffusion-weighted MRI (DW-MRI) in wild-type (WT) mice, the acute systemic administration of pregabalin incre...

BACKGROUND Preoperative administration of pregabalin is proposed as a promising way of enhancing postoperative pain control. Whereas a few studies have investigated the effect of pregabalin on postoperative opioid consumption, no study has focused on the influence on postoperative hyperalgesia. In this randomized, triple-blinded, placebo-controlled study, we aimed to demonstrate that a single, ...

BACKGROUND Pregabalin has been used as an adjunct for the management of acute pain in laparoscopic cholecystectomy. This meta-analysis aimed to illustrate the efficacy and safety of pregabalin for pain management following laparoscopic cholecystectomy. METHODS In March 2017, a systematic computer-based search was conducted in PubMed, EMBASE, Web of Science, Cochrane Database of Systematic Rev...

Methods: Pregabalin utilization and its impact on concomitant medication use were assessed via a retrospective evaluation of 387 patients treated at Lahey Clinic Interventional Pain Management Center. Using an e-prescribing database, records were reviewed to assess utilization of pregabalin and concomitant medications for 3 months prior to and after the initiation of therapy. We assumed patient...

BACKGROUND The aim of the study was to determine the type of interaction between pregabalin (a 3(rd)-generation antiepileptic drug) and WIN 55,212-2 mesylate (WIN - a highly potent non-selective cannabinoid CB1 and CB2 receptor agonist) administered in combination at a fixed ratio of 1:1, in the acute thermal pain model (hot-plate test) in mice. METHODS Linear regression analysis was used to ...

OBJECTIVE To compare the relative healthcare costs, from the perspective of the Spanish National Healthcare System (NHS), of initiating treatment with either pregabalin, or SSRI/SNRI, as add-on therapies, in patients with generalized anxiety disorder (GAD), who are resistant to benzodiazepine-based therapy (BR). METHODS BR out-patients with GAD (DSM-IV) who were included in a 6-month, prospec...

CONTEXT AND OBJECTIVE To describe clinical and resource utilization patterns in patients with refractory neuropathic pain (NeP) who were prescribed pregabalin for the first time in routine medical practice in primary care settings. METHODS Post-hoc analysis of a 12-week prospective observational study including pregabalin naïve adult patients with refractory chronic NeP of at least 6-months d...

We aimed to summarize the efficacy of pregabalin in the treatment of postherpetic neuralgia (PHN) in pain reduction, sleep improvement and overall improvement of the patients in published studies. A literature search for randomized clinical trials (RCTs) investigating the efficacy of pregabalin for PHN was carried out in PubMed, EMBASE and the Cochrane database. For each trial met the inclusion...