The diagnosis of spontaneous premature ovarian failure can be a difficult one for young women, especially those desiring fertility. These women fare best when their clinicians understand and are prepared to meet the special needs that arise from this diagnosis.

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OBJECTIVE To investigate the incidence of ovarian failure after pulse cyclophosphamide treatment in systemic lupus erythematosus (SLE) and to compare this with two control groups: SLE patients treated with azathioprine, and a healthy age matched population. METHODS All women patients with SLE treated with pulse cyclophosphamide in our department were identified and questioned concerning menst...