Abstract Ovarian reserve is essential for fertility and influences healthy aging in women. Advanced maternal age correlates with the progressive loss of both quantity quality oocytes. The molecular mechanisms various contributing factors underlying ovarian have been uncovered. In this review, we highlight some critical that impact oocyte during aging. Germ cell follicle at birth determines repr...

Early menopause or premature ovarian insufficiency (POI) is a common cause of infertility in women and affects about one per cent of young women. This disorder has significant psychological sequelae and major health implications. Its relevance has increased in recent years due to the fact that age of motherhood is being delayed in developed countries, with the risk of having either primary ovar...

Primary ovarian insufficiency or premature ovarian failure (POI/POF) is one the causes of female infertility. POI is defined as cessation of menstrual periods, increased levels of FSH and diminished levels of estrogens before the age of 40. POI occurs in about 1% of women between 30 to 40 years of age, 0.1% of those under 30 and 0.01% of women under the age of 20. Fertility of women with POI is...