OBJECTIVE To evaluate whether prenatal use of non-steroidal anti-inflammatory drugs (NSAIDs) is associated with increased risk of miscarriage. DESIGN Population based cohort study. Prenatal use of NSAIDs, aspirin, and paracetamol (acetaminophen) ascertained by in-person interview. SETTING Kaiser Permanente Medical Care Program, a healthcare delivery system, in the San Francisco area of the ...

OBJECTIVES To determine the accuracy of prenatal diagnosis of pulmonary atresia and intact ventricular septum (PAIVS), and pulmonary stenosis, including prenatal detection of ventriculocoronary connections, to evaluate heart size during the prenatal period, and to evaluate the outcome. DESIGN AND PATIENTS Medical records of 20 cases with prenatally diagnosed PAIVS and pulmonary stenosis were ...

The emergence of effective cell-free fetal DNA-based techniques to screen for trisomy 21 and other aneuploidies has greatly expanded the range of prenatal tests available over the last few years. Non-invasive prenatal testing (NIPT) is rapidly being incorporated into prenatal care, thus changing the traditional approach to prenatal screening and diagnosis. However, although NIPT techniques are ...

OBJECTIVES To evaluate the accuracy of ultrasound in the diagnosis of placenta accreta and its variants, and to assess the impact of prenatal diagnosis in our population. METHODS A total of 314 women with placenta previa were enrolled prospectively and underwent transabdominal and transvaginal ultrasound examinations. An ultrasound diagnosis (grayscale and color/power Doppler) of placental at...

Maternal, fetal and neonatal complications are correlated with hypertensive disorders during pregnancy.  In this context, the maternal blood uric acid level is reported to be one of the prognostic factors in determining the prenatal outcome.  Based on the existing data, the present descriptive study was performed on two groups of women with severe preeclampsia; the first group (n=53) with a uri...

BACKGROUND To evaluate the impact of the introduction of prenatal screening on time of detection and pregnancy outcome for trisomy 21 (T21), trisomy 18 (T18) and trisomy 13 (T13). METHODS We performed a retrospective, population-based cohort study in the Northern Netherlands including 503 trisomy cases born between 2005 and 2012. Screening tests and invasive procedures, timing of diagnosis an...

BACKGROUND Prenatal care coverage is still not universal or adequately provided in many low and middle income countries. One of the main barriers regards the presence of socioeconomic inequalities in prenatal care utilization. In Brazil, prenatal care is supplied for the entire population at the community level as part of the Family Health Strategy (FHS), which is the main source of primary car...

The prenatal obstetric ultrasound community has moved substantially towards recognition of the benefits of a prenatal diagnosis since the unfortunate impact of the underpowered RADIUS study that showed no benefit of prenatal ultrasound1. Prenatal diagnosis of critical isolated congenital heart disease (CHD) confers benefit by reducing neonatal morbidity and mortality, particularly in cases with...

OBJECTIVE Prenatal exposure to antiepileptic drugs (AEDs) has been associated with adverse outcomes in the offspring such as congenital malformations and neuropsychiatric disorders. The objective of this study was to investigate whether prenatal exposure to AEDs is also associated with more frequent use of primary healthcare during childhood. DESIGN Population-based cohort study. SETTING Na...

OBJECTIVES The objective of this study was to examine whether maternal exposure to asthmogens during pregnancy is associated with the development of asthma in 7-year-old Danish children, taking atopic status and sex into consideration. DESIGN The study is a prospective follow-up of a birth cohort. SETTING AND PARTICIPANTS A total of 41 724 women and their children from The Danish National B...