Studies of the amidase activity ofextracts of various animal tissues have been reported in earlier papers (Bray, James, Ryman & Thorpe, 1948; Bray, James, Raffan, Ryman & Thorpe, 1949a; Bray, Thorpe & Wood, 1949c; Bray, James, Thorpe, Wasdell & Wood, 1949 b). The present paper records further observations, including the behaviour of the enzyme towards some saturated long-chain and w-phenylsubst...

Amino-amides are important pharmaceutical building-blocks. The enantioselective reduction of trichloromethyl ketones using ruthenium transfer hydrogenation catalysts is reported. The products react in a range of Jocic-type reactions to give enantiomerically enriched amino-amides.

wall carbohydrates, and organic acids. The hydroxycinnamic acid amides with tyramine and octopamine are also common types of conjugates.2) The formation of the amides serves a defensive purpose in solanaceous plants such as potato,3・4) tobacco5) and tomato.6) Various forms of stress, including physical injury, infection with pathogens and elicitor-treatments, induce the accumulation of hydroxyc...

Bisamides are key fragments for the introduction of gem-diaminoalkyl residues into retroinverso pseudopeptide derivatives and in the synthesis of peptidomimetic compounds. The literature methods for these types of compounds have certain drawbacks. In particular, when amides react with electrophile-activated DMSO, the yields are rather low. We have found new electrophiles, 2,4,6-trichloro[1,3,5]...

An efficient and general copper-catalyzed Goldberg reaction at 90-110 °C between aryl bromides and amides providing the desired products in good to excellent yields has been developed using N,N-dimethylglycine as the ligand. The reaction is tolerant toward a wide range of amides and a variety of functional group substituted aryl bromides. In addition, hindered, unreactive aromatic and aliphatic...

Amides are a class of easily available and highly stable compounds. Secondary amides also serve as powerful directing groups in C H activation. Ketones are also a class of extremely versatile molecules that enable a number of fundamental transformations in organic synthesis. Hence the transformation of amides into ketones is of high relevance in organic synthesis. However, because of the high s...

the synthesis of aryl amides via the reactions of carboxylic acids and isocyanides in methanol was carried out in 78-95% yields under ultrasound irradiation. the method has wide applicability, and the protocol is mild, fast and efficient compared to the existing methods based on silent conditions.