Let R be a prime ring with a right generalized (α, β)derivation f and let a ∈ R. Suppose that af(x)n = 0 for all x ∈ R, where n is a fixed positive integer. Then af(x) = 0 for all x ∈R. In particular, if f is either a regular right generalized (α, β)-derivation or a nonzero generalized (α, β)-derivation, then a = 0. In [13] I. N. Herstein proved that if R is a prime ring and d is an inner deriv...