Background—The pharmacological treatment of essential tremor (ET) is not optimal. There are only two first-line medications and troublesome side effects are common. It is not uncommon for patients to simply stop taking medication. Yet no published data substantiate or quantify this anecdotal impression. Objectives—To determine, among ET patients who were prescribed medication for tremor, what p...

Aim: Little is known about the consumption of antiepileptic drugs in pregnancy in the Czech Republic, particularly for newer agents. In our previous paper, we discussed long-term trends in the utilization of antiepileptic drugs during pregnancy in a group of 235 women between 1991–2006. Currently, we continue to investigate the long-term trends in antiepileptic drug use in pregnant women. Metho...

objectives: anticonvulsant drugs can cause various forms of skin drug reactions, ranging from exanthema to severe blistering reactions. some studies have reported an association between hla-b*1502 allele and severe skin reactions. materials and methods: fifteen patients with severe skin reactions following treatment with anticonvulsant drugs (carbamazepine, lamotrigine, phenobarbital, primidone...

Introduction: The Antiepileptic medications are frequently categorized into divisions such as ‘first-generation’ (i.e., carbamazepine, phenobarbital, phenytoin, primidone, and valproate) ‘second-generation’ (lamotrigine, levetiracetam, felbamate, gabapentin, topiramate, tiagabine, oxycarbazepine, zonisamide, pregabalin). Chronic phenytoin ingestion leads to its impact in the cerebral cortex, re...

Background: Epilepsy is the second common neurologic disorder. Although many antiepileptic drugs have been formulated to control the seizures, but not all seizures have been controlled by them. Uncontrolled epilepsy can actually reduce the patients’ quality of life. Objectives: Identifying the proportion of adult intractable epilepsy among epileptic patients in an area in the North East o...