BACKGROUND We conducted a meta-analysis of randomized trials of ranibizumab for age-related macular degeneration (AMD) to elucidate systemic vascular risk. CLINICAL RELEVANCE Although intravitreal vascular endothelial growth factor inhibitors are widely used to treat AMD, whether they produce systemic adverse effects remains uncertain. METHODS We searched MEDLINE, EMBASE, and Cochrane Centr...

In practice, a GPS receiver must first replicate the PRN code that is transmitted by the SV being acquired by the receiver; then it must shift the phase of the replica code until it correlates with the SV PRN code. When cross-correlating the transmitted PRN code with a replica code, the same correlation properties occur that occurs for the mathematical autocorrelation process for a given PRN co...

The purpose of this study was to examine the disposition of diphenhydramine (DPHM) across the ovine blood-brain barrier (BBB). In six adult sheep, we characterized the central nervous system (CNS) pharmacokinetics of DPHM in brain extracellular fluid (ECF) and cerebrospinal fluid (CSF) using microdialysis in two experiments. In the first experiment, DPHM was administered via a five-step i.v. in...

The premature primate exposed to hyperoxia provides a useful model of bronchopulmonary dysplasia. A critical target in hyperoxic injury is the mitochondrial matrix enzyme aconitase. We hypothesized that this enzyme's activity would decline in the premature baboon lung during exposure to hyperoxia. Total aconitase activity was significantly decreased in the lungs of premature baboons of 140 days...

The calibration of correlation radiometers, and particularly aperture synthesis interferometric radiometers, is a critical issue to ensure their performance. Current calibration techniques are based on the measurement of the cross-correlation of receivers' outputs when injecting noise from a common noise source requiring a very stable distribution network. For large interferometric radiometers ...

The Packet Radio Network (PRN) is an attractive architecture to support wireless data communication. The code assignment problem in PRN is a classical problem that has been extensively studied. However, in this paper we observe that the power control issue has been ignored by most works, but may have significant impact on PRN’s performance. Given a set of PRN stations, the network topology can ...

During colonization of the respiratory tract by Bordetella pertussis, virulence factors contribute to adherence of the bacterium to the respiratory tract epithelium. In the present study, we examined the roles of the virulence factors filamentous hemagglutinin (FHA), fimbriae, pertactin (Prn), and pertussis toxin (PT) in the adherence of B. pertussis to cells of the human bronchial epithelial c...

Regeneration involves precise control of cell fate to produce an appropriate complement of tissues formed within a blastema. Several chromatin-modifying complexes have been identified as required for regeneration in planarians, but it is unclear whether this class of molecules uniformly promotes the production of differentiated cells. We identify a function for p66, encoding a DNA-binding prote...

The variability of ionospheric response to the total solar eclipse of 22 July 2009 has been studied analyzing the GPS data recorded at the four Indian low-latitude stations Varanasi (100 % obscuration), Kanpur (95 % obscuration), Hyderabad (84 % obscuration) and Bangalore (72 % obscuration). The retrieved ionospheric vertical total electron content (VTEC) shows a significant reduction (reflecte...