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Even as the world continues to grieve for those lost SARS-CoV-2 pandemic, another pandemic is brewing that has potential kill hundreds of millions people in a century or less. In far future, patients’ lives are being cut short hospital wards by stealthy but widespread epidemic antimicrobial resistance. Unfortunately, global health community now confronting silently growing could threaten some m...
Abstr"ct-Bayesian inference systems should be able to explain their reasoning to users, translating from numerical to natural language. Previous empirical work has investigated the correspondence between absolute probabilities and linguistic phrases. This study extends that work to the correspondence between changes in probabilities (up d ates) and relative probability phrases, such as ''much m...
conclusions a significant proportion of coronary atherosclerotic plaques in cadavers with confirmed acute myocardial infarction were detected to be infected with cytomegaloviruses while no infections of c. pneumoniae and h. pylori were detected. patients and methods sixty cadavers in two equal groups were analyzed. acute myocardial infarction group included cadavers with acute myocardial infarc...
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The development of acute myeloid leukemia (AML) is a multistep process that requires at least two genetic abnormalities for the development of the disease. The identification of genetic mutations in AML has greatly advanced our understanding of leukemogenesis. Recently, the use of novel technologies, such as massively parallel DNA sequencing or high-resolution single-nucleotide polymorphism arr...
Ten-eleven translocation (TET) family enzymes convert 5-methylcytosine to 5-hydroxylmethylcytosine. However, the molecular mechanism that regulates this biological process is not clear. Here, we show the evidence that PGC7 (also known as Dppa3 or Stella) interacts with TET2 and TET3 both in vitro and in vivo to suppress the enzymatic activity of TET2 and TET3. Moreover, lacking PGC7 induces the...
Although a role for oncogenic KIT in driving mast cell disease is clear, the mechanisms driving the multiple phenotypic and clinical manifestations of this disorder are not well elucidated. We now show, using a large cohort of mastocytosis patients, including an almost equal number of aggressive and nonaggressive cases of systemic mastocytosis, that in contrast to the oncogenic KITD816V, TET2 m...
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