نتایج جستجو برای: procainamide hcl

تعداد نتایج: 12185  

Journal: :Chembiochem : a European journal of chemical biology 2012
Ludovic Halby Christine Champion Catherine Sénamaud-Beaufort Sophie Ajjan Thierry Drujon Arumugam Rajavelu Alexandre Ceccaldi Renata Jurkowska Olivier Lequin William G Nelson Alain Guy Albert Jeltsch Dominique Guianvarc'h Clotilde Ferroud Paola B Arimondo

DNA methyltransferases (DNMTs) are responsible for DNA methylation, an epigenetic modification involved in gene regulation. Families of conjugates of procainamide, an inhibitor of DNMT1, were conceived and produced by rapid synthetic pathways. Six compounds resulted in potent inhibitors of the murine catalytic Dnmt3A/3L complex and of human DNMT1, at least 50 times greater than that of the pare...

2010
Lee Kyoung Kim Chul Seung Lee Jun Gong Jeun

An 82-year-old female, with left femoral neck fracture was scheduled for left hip hemiarthroplasty, under spinal anaesthesia. She had been suffering from diabetes, hypertension, lung cancer and was previously treated with IV aminophylline for respiratory insufficiency. She was given spinal anaesthesia with 10 mg of 0.5% hyperbaric bupivacaine, and T6 sensory block level was established. After 1...

2011
Xavier Troussard Edouard Cornet X. Troussard

Hairy-cell leukemia (HCL) is a rare hematologic malignancy. HCL diagnosis can be difficult and the variant form of HCL (HCL-V) has similarities with B-cell prolymphocytic leukemia or splenic marginal zone lymphoma. We describe the different features of HCL, particularly typical HCL (HCL-C) and HCL-V. HCL prognosis was transformed by the introduction of purine nucleoside analogues such as Cladri...

Journal: :Annals of the rheumatic diseases 1976
Y Levo A I Pick I Avidor M Ben-Bassat

A patient who developed a multisystem involvement of systemic lupus erythematosus (SLE) after 9 years of procainamide therapy, during which time he ingested enormous amounts of the drug, is described. The patient first suffered from recurrent episodes of pleuritis and arthritis, after which he developed a characteristic SLE nephritis associated with a high level of antinative DNA antibodies and...

Journal: :Swiss Medical Forum ‒ Schweizerisches Medizin-Forum 2007

2005
WAYNE E. CASCIO JACK W. BUCHANAN TIMOTHY A. JOHNSON

Procainamide, a type 1A antiarrhythmic drug, blocks sodium channels and reduces the maximum rate of rise of the cardiac action potential (Vmax) in a rate-dependent fashion. In vitro, the magnitude of this rate-dependent reduction in Vmax is greater in tissue that is partially depolarized at rest than in tissue with a normal resting potential. Reductions in Vmax produced by drugs that block sodi...

Journal: :acta medica iranica 0
haghighati f arefi v

citric acid and tetracycline hcl are the most common clinical root demineralization agents used in periodontal practice. in this comparative in vitro study the effects of nd: yag laser radiation on root surface was compared to that of citric acid and tetracycline hcl using sem. a total of twenty-one freshly extracted periodontally diseased single rooted premolar teeth were root planned in vitro...

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