An understanding of material properties and processing effects on solid dosage forms performance is required within the Quality-by-design approach to pharmaceutical development. Several research groups have developed mathematical approaches aiming facilitate selection formulation composition manufacturing technology. These are based particulate, bulk compression-related properties. This paper p...

This study investigated the effect of milk somatic cell count (SCC) and polymorphonuclear leucocyte (PMN, or neutrophil) content on the processability of milks from individual udder quarters. Two milk samples of high and low SCC (6x10 and 920x10/ml, respectively) and two of high and low PMN content (<1x10 and 700x10/ml, respectively) were selected. The milk samples were mixed in appropriate pro...

Polyoxometalates (POMs), a type of giant transition metal oxide clusters on the nanoscale, are emerging as useful materials with unique catalytic, electrooptical, and biological properties. Lanthanide-containing POMs elements show excellent photoluminescent properties with narrow emission bands, large Stokes shift, long lifetime, and tunable emission, i.e., their long emission timescale (microt...

Polymorphs of an Active Pharmaceutical Ingredient (API) can have different chemical and physical properties and, thus, a direct impact on the processability of the drug substance and the quality/performance of the drug product, such as stability, dissolution, and bioavailability. Therefore, identification of the crystal phase of an API is of outmost importance. In this work methodologies were d...

The 2024 aluminum alloy (Al-Cu-Mg) is widely used in aerospace; however, due to its solidification-cracking tendency, processability using laser powder bed fusion (LPBF) remains a critical issue. addition of 2 wt% CaB6 nanoparticles induces columnar-to-equiaxed transition (CET), resulting an immediate improvement LPBF processability. High-density (>99.5%) and crack-free specimens, with homogene...