This study aimed to determine the effects of different lengths progesterone and equine chorionic gonadotropin (eCG) treatment on reproductive performance during non-breeding season in ewes. Progesterone-impregnated sponges were inserted intravaginally for 7 d Group 1 (G1, n = 24), 9 2 (G2, 25), 11 3 (G3, 24). On day sponge removal, eCG (350 IU) was injected 24 h later ewes exposed rams. Pregnan...

This study investigated the transdermal uptake and subsequent tissue distribution of [(3)H]progesterone applied in a commercially available progesterone cream in a rat model. Concentrations of lipid- and water-soluble metabolites of [(3)H]progesterone were also measured in plasma, urine and selected tissues (uterus, liver, kidney, salivary gland) 3 h after its topical application. Female rats w...

During cholestatic liver diseases, cholangiocytes express neuroendocrine phenotypes and respond to a number of hormones and neuropeptides by paracrine and autocrine mechanisms. We examined whether the neuroendocrine hormone progesterone is produced by and targeted to cholangiocytes, thereby regulating biliary proliferation during cholestasis. Nuclear (PR-A and PR-B) and membrane (PRGMC1, PRGMC2...

The involvement of the arachidonic acid (AA) products, noradrenaline (NA) and LH in the stimulatory effect of progesterone on its own synthesis was tested using slices of CL from days 5-10 of the oestrous cycle of cow. Slices of CL (45-50 mg) were pre-incubated for 24 h, then the medium was replaced with fresh medium and 45 min later was supplemented with LH (100 ng/ml) as a positive control, o...

BACKGROUND AND PURPOSE We have previously shown that female animals experience substantial protection from brain injury after reversible middle cerebral artery occlusion (MCAO) compared with their male or ovariectomized female counterparts. The reproductive steroid estrogen has been shown to provide neuroprotection from a variety of experimental insults, but the importance of progesterone as an...

Recent studies have shown that progesterone, a sex steroid hormone, enhances the sexual transmission of various pathogens, including SIV. The goal of this study was to determine whether progesterone affects mechanisms underlying the sexual transmission of HIV-1. We first studied the effects of various physiologic concentrations of progesterone on the expression of chemokines and chemokine recep...

The possibility that the female sex steroid progesterone plays a role in meningioma proliferation has been suggested by a number of investigators; and it had been shown that many meningiomas have high affinity progesterone binding sites. The aim of this study was to examine the expression of progesterone receptor mRNA and correlate it with the nuclear localization of progesterone receptor by im...

BACKGROUND The use of progesterone for luteal support has been demonstrated to be beneficial in assisted reproductive cycles, yet the optimal route of progesterone administration has still not been established. This article is a retrospective study in a tertiary reproductive medical unit to compare luteal progesterone supplementation with vaginal gel or intramuscular progesterone. METHODS A t...

Monoamine oxidase activity was measured in the brains and uteri of neonatal rats exposed to preand/or postnatal progesterone. Daily doses of progesterone were injected subcutaneously into pregnant females on gestational days 8-17 and postpartum days 2-6. On postpartum day 1, half of the pups of each litter were crossfostered to a female in the opposite experimental condition. Pups were sacrific...

Various studies have shown that pregnancy is associated with gastrointestinal complaints that might result from disturbance of the normal contractile pattern of smooth muscle. Progesterone is an important steroid hormone, which plays a crucial role in female pregnancy. Progesterone affects muscle cells by genomic mechanisms, through nuclear receptors, and non-genomic mechanisms, through unident...