The purpose of these studies was to determine the intracellular signal transduction pathways of bacterial products in murine macrophages from lipopolysaccharide (LPS)-responder C3H/HeN and LPS-nonresponder C3H/HeJ mice. Both LPS and synthetic lipopeptide CGP 31362 (LPP) induced production of tumor necrosis factor alpha (TNF-alpha) in C3H/HeN macrophages. In C3H/HeJ macrophages, however, TNF-alp...

Supplier selection and evaluation is increasingly seen as a strategic issue for companies. Unlike the past, an emerging trend is to select suppliers where a long-term relationship is desired and supplier involvement in product development is required and to sort suppliers into categories based on performances. This paper describes a supplier evaluation and management methodology for strategic s...

The late positive potential (LPP), which is reduced following the use of reappraisal, is a potential neurosignature for emotion regulation capacity. This sensitivity of the LPP to reappraisal is rarely studied in children. We tested whether, in 26 typically developing seven- to nine-year-olds, LPP amplitudes were reduced following reappraisal and whether this effect varied with age and anxiety....

Optimization of the complete manufacturing and supply process has become a critical ingredient for gaining a competitive advantage. This article provides a unified mathematical framework for modeling manufacturing cell configuration and raw material supplier selection in a two-level supply chain network. The commonly used manufacturing design parameters along with supplier selection and a subco...

In today's competitive markets, firms try to reduce their supply cost by selecting efficient suppliers using different techniques. Several methods can be applied to evaluate the efficiency of supplier base. This paper develops generalized network data envelopment analysis models to examine the efficiency of two-tier supplier bases under cooperative and non-cooperative strategies where each tier...

Suppliers have become resources for innovation and competitive advantages. To realize those potentials specific competencies have to be developed in a partnership between customer and supplier. The success of those development projects and also the effort that has to be put in depend on several factors. One of those factors is the motivation of the supplier organization. An empirical study show...

The late positive potential (LPP) is a reliable electrophysiological index of emotional perception in humans. Despite years of research, the brain structures that contribute to the generation and modulation of LPP are not well understood. Recording EEG and fMRI simultaneously, and applying a recently proposed single-trial ERP analysis method, we addressed the problem by correlating the single-t...

in mammals, the intrauterine condition has an important role in the development of fetal physiological systems in later life. suboptimal maternal environment can alter the regulatory pathways that determine the normal development of the fetus in utero, which in post-natal life may render the individual more susceptible to cardiovascular or metabolic adult-life diseases. changes in the intrauter...

Supply chain management is an increasingly important organizational concern, and proper management of supplier relationships constitutes one essential element of supply chain success (Fawcett and Fawcett, 1995; Giunipero and Brand, 1996). Buying firms faced with problems of deficient supplier performance and/or capabilities can implement a wide range of supplier development practices in order t...

The aim of this paper is to identify antecedents to supplier integration in China. A deductive approach was deployed by building on a qualitative pre-study and various strands of SCM literature. All in all, 14 hypotheses were derived and subsequently tested by drawing on an empirical sample collected from 88 manufacturing firms operating in China. The data was then analyzed using partial least ...