We extend Cox’s classical regression model to accomodate partially informative censored data. In this type of data, each observation is the minimum of one lifetime and two censoring times. The survival function of one of these censoring times is a power of the survival function of the lifetime. We call this the informative censoring time. The distribution of the other censoring time has no rela...

Subject motion degrades the quality of task functional magnetic resonance imaging (fMRI) data. Here, we test two classes of methods to counteract the effects of motion in task fMRI data: (1) a variety of motion regressions and (2) motion censoring ("motion scrubbing"). In motion regression, various regressors based on realignment estimates were included as nuisance regressors in general linear ...

Abstract We propose a variational inference-based framework for training Gaussian process regression model subject to censored observational data. Data censoring is typical problem encountered during the data gathering procedure and requires specialized techniques perform inference since resulting probabilistic models are typically analytically intractable. In this article we exploit sparse ind...

Some fully general parametric competing risks models, which allow the underlying (possibly dependent) lifetimes to be modeled as a function of an arbitrary number of covariables, are formulated, and their resulting likelihood function is derived. Under carefully stated regularity conditions, large sample tests of hypotheses concerning the model parameters are obtained for the single point trunc...

BACKGROUND When developing a prediction model for survival data it is essential to validate its performance in external validation settings using appropriate performance measures. Although a number of such measures have been proposed, there is only limited guidance regarding their use in the context of model validation. This paper reviewed and evaluated a wide range of performance measures to p...

Mixed effects models are often used for estimating fixed effects and variance components in longitudinal studies of continuous data. When the outcome being modelled is a laboratory measurement, however, it may be subject to lower and upper detection limits (i.e., censoring). In this paper, the usual EM estimation procedure for mixed effects models is modified to account for left and/or right ce...

When the event time of interest depends on the censoring time, conventional two-sample test methods, such as the log-rank and Wilcoxon tests, can produce an invalid test result. We extend our previous work on estimation using auxiliary variables to adjust for dependent censoring via multiple imputation, to the comparison of two survival distributions. To conduct the imputation, we use two worki...

Type I and Type II censored data arise frequently in controlled laboratory studies concerning time to a particular event (e.g., death of an animal or failure of a physical device). Log-location-scale distributions (e.g., Weibull, lognormal, and loglogistic) are commonly used to model the resulting data. Maximum likelihood (ML) is generally used to obtain parameter estimates when the data are ce...

In clinical research, the occurrence of certain events (e.g., adverse events, disease progression, relapse, or death) is often of particular interest to the investigators, especially in the area of cancer trials. In most situations, these events are undesirable and unpreventable. In practice, it would be beneficial to patients if the test treatment could delay the occurrence of such events. As ...