A double-blind study of 700 healthy children was done in an attempt to investigate the effectiveness of promethazine (Phenergan) with regard to the incidence and severity of ketamine-induced emergence phenomena. This study indicates that preoperative administration of Phenergan syrup is effective in reducing postoperative psychomimetic reactions, recovery time, patient apprehension, and the inc...

BACKGROUND Effects of the H1-antihistamine, cetirizine, were studied on daytime alertness and performance to establish whether the drug would be suitable for use by air personnel and others involved in skilled activity. METHODS The investigation was carried out in six healthy volunteers, and the effects of the drug (5, 10, and 15 mg) were studied on sleep latency, subjective sleepiness, digit...

To the Editor:-Anesthetic implications of neurofibromatosis may include airway, mediastid and vertebral neurofibromas, associated endocrine syndromes, and intracranial masses in 510% of patients. ’ Hydrocephalus is a rare manifestation of neurofibromatosis and is commonly descrihed during the first two decades of lie.’-* We present a case of acute postoperative hydrocephalus in a previously hea...

This article reviews clinical pharmacokinetic data on the H1-receptor antagonists, commonly referred to as the antihistamines. Despite their widespread use over an extended period, relatively little pharmacokinetic data are available for many of these drugs. A number of H1-receptor antagonists have been assayed mainly using radioimmunoassay methods. These have also generally measured metabolite...

the objective of this investigation was the development of chitosan/xanthan polyelectrolyte complex based mucoadhesive nasal insert of promethazine hydrochloride a drug used in the treatment of motion sickness. a 32 factorial design was applied for preparing chitosan/xanthan polyelectrolyte complex and to study the effect of independent variables i.e. concentration of xanthan [x1] and concentra...