As cancer therapy has progressed dramatically, its goal has shifted toward cure of the disease (curative therapy) rather than prolongation of time to death (life-prolonging therapy). Consequently, the proportion of cured patients (c) has become an important measure of the long-term survival benefit derived from therapy. In 1949, Boag addressed this issue by developing the parametric log-normal ...

In this paper, a modified delayed mathematical model for the dynamics of HIV with cure rate is considered. By regarding the time delay as bifurcation parameter, stability and existence of local Hopf bifurcation are studied by analyzing the transcendental characteristic equation. Then the global existence of bifurcating periodic solutions is established with the assistance of global Hopf bifurca...

I n this issue of Haematologica, Gatta et al. describe cure trends for children and adolescents with acute lymphoblastic leukemia (ALL) who were diagnosed between 1982 and 2002, analyzing data obtained from various cancer registries across Europe. 1 The good news is that the projected proportion of cured children increased significantly over the study period, especially in children in the good ...

the gastric cancer in iran is the fourth in the general population. this study was designed to determine the five-year survival rate of gastric cancer patients, and to assess its associated factors. we analyzed the data using a time-dependent covariates model, and recommend it for analyses of similar data. 281 gastric cancer patients with adenocarcinomatous pathology who had been operated on at...

BACKGROUND A new class of immuno-oncology agents has recently been shown to induce long-term survival in a proportion of treated patients. This phenomenon poses unique challenges for the prediction of analysis time in event-driven studies. If the phenomenon of long-term survival is not accounted for properly, the accuracy of the prediction based on the existing methods may be substantially comp...

Over the years, researchers have found that promotion makes consumers switch brands and purchase earlier or more. However, it is unclear how promotion affects consumption, especially for product categories that are perceived to be versatile and substitutable. In this paper, we propose a dynamic structural model with endogenous consumption under promotion uncertainty to analyze the promotion eff...

background: loneliness is one of the most significant problems during aging. this research has been done to determine the effect of a multi-strategy program based on pender’s health promotion model to prevent loneliness of elderly women by improving social relationships. methods: in this quasi-experimental study done in 2013 from january to november, 150 old women suffering medium loneliness re...