mone (LH). The increase in rats is preceded by increases in ovarian levels of cyclic AMP and progesterone. Systemic administration of indomethacin prevented the increase of ovarian prostaglandin F and blocked ovulation in rabbits and rats. Intrafollicular injection of indomethacin, in rabbits, at dosages which were ineffective when given via systemic injection, blocked the elevation of follicul...

Objective- To studylocal effect of prostaglandin E1on sciatic nerve regeneration Design- Experimental study Animals- Sixty male healthy white Wistar rats Procedures- Sixty animals were divided into four experimental groups (n = 15), randomly: Trasnsected (TC), Sham-operation (SHAM), control (CHIT) and prostagl...

Abstract Here we report application of human umbilical cord mesenchymal stem cell (HUCMSC)-derived therapy for pulmonary arterial hypertension (PAH). A 3-year-old female presented with heritable PAH associated hereditary hemorrhagic telangiectasia and was treated 6 months serial intravascular infusions conditioned media (CM) from allogenic HUCMSCs. The treatment markedly improved clinical hemod...

The platelets from 74 patients with acute myocardial infarction or with unstable angina showed decreased prostaglandin E1/12 receptor activity when compared with that of 56 normal volunteers by using [3H]prostaglandin E1 as a probe. In normals, Scatchard analyses showed the presence of one high-affinity-low-capacity (Kd1=9.0±1.2 nM [mean±SD]; n1=120±30 sites/cell) and one low-affinity-high-capa...

The goal of this study was to determine the role of prostanoids in a new model of mineralocorticoid-dependent hypertension induced by the subcutaneous infusion of aldosterone (1 micrograms/hr) to normal male Sprague-Dawley rats. This regimen caused a mild and gradual increase in systolic pressure over a period of 4 weeks (113 +/- 1 vs. 137 +/- 3 mm Hg) and was associated with an increase in the...

STATEMENT OF THE PROBLEM A major objective of investigators is to clarify the role of metabolites in achievement of maximum tooth movement with minimal root damage during orthodontic tooth movement (OTM). PURPOSE The aim of this study was to determine the effect of administration of thyroid hormone, prostaglandin E2, and calcium on orthodontic tooth movement and root resorption in rats. MAT...

This study was designed to examine the effects of diets that alter prostaglandin biosynthesis on the blood pressure in one-kidney, one clip rats with established hypertension and to compare the prostanoid generating capacity of hypertensive animals with those that remained normotensive. Rats attaining blood pressures of at least 180 mm Hg within 8 weeks of nephrectomy and renal artery stenosis ...