BACKGROUND To characterise the association between demographic and clinical factors and levels of total prostate specific antigen (tPSA) and its molecular derivatives complexed PSA (cPSA), free PSA (fPSA) and the ratio of free to total PSA (%fPSA)] in New Zealand Maori, Pacific Islanders and Europeans, in order to determine whether reported ethnic differences in PSA can be explained by lifestyl...

Abstract Prostate cancer screening based on prostate-specific antigen (PSA) testing has been a matter of controversy. Although for prostate was effective in reducing mortality, it resulted overdiagnosis, which translated into unnecessary treatments and numerous adverse effects. As result, recommendations from scientific societies became increasingly restrictive. In the recent years, new approac...

Background and Objective: Prostate cancer is a prevalent disease around the world. The prostatic specific Antigen (PSA) test has recently proved itself as a useful method for the diagnosis and examination of patients with prostatic cancer. The objective of this study was to compare the stability of free PSA and total PSA in different storage settings. Materials and Method...

PURPOSE Although showing a 25% reduction in the biopsy prevalence of cancer compared with placebo in the Prostate Cancer Prevention Trial, finasteride was associated with a higher prevalence of high-grade disease. This observation was driven by "for-cause" biopsies. We sought to understand how volume-dependent changes in prostate-specific antigen test performance characteristics may have contri...

OBJECTIVES To assess the ability of preoperative prostate-specific antigen level, Gleason score and stage to predict prostate cancer outcomes beyond biochemical recurrence, specifically castration-resistant prostate cancer, metastases and prostate cancer-specific mortality in radical prostatectomy patients. METHODS We carried out a retrospective study of 2735 men in the Shared Equal Access Re...

BACKGROUND Prostate cancer is the fourth most common cancer worldwide and is the second most lethal cancer. OBJECTIVES The aim of this study was to investigate psychological predictors of prostate cancer screening behaviors among men over 50 years of age in Hamadan. MATERIALS AND METHODS This cross-sectional study was carried out on 200 men over 50 years of age in Hamadan, west of Iran. Par...

Prostate cancer (PC) is reported as an important neoplasm worldwide, caused by the uncontrolled multiplication of cells in prostate. The main risk factors are age over 50 years, family history, genetic susceptibility, hormonal disorders, obesity and environmental factors. Active surveillance low-risk PC defers aggressive treatment until disease progression increasingly recommended strategy. Thi...