background and purpose: many workers are exposed to workplace hazards. many occupational diseases are preventable by personal protective devices (ppds). though many workers do not use ppds or their protection by ppds is not sufficient. this study was designed to assess the quality of ppds usage among industrial workers. materials and methods: in a cross-sectional study, 648 workers from four ma...

Although pili have long been recognized in Gram-negative pathogens as important virulence factors involved in adhesion and invasion, very little is known about extended surface organelles in Gram-positive pathogens. Here we report that Group A Streptococcus (GAS), a Gram-positive human-specific pathogen that causes pharyngitis, impetigo, invasive disease, necrotizing fasciitis, and autoimmune s...

background: toxoplasma gondii is an obligate intracellular parasite that infects all mammalian cells. several antigens such as excreted/secreted antigens have been identified as a potential vaccine candidate. objective: to determine how excreted/secreted antigens from peritoneal exudates of infected mice (mesa) stimulate cell-mediated immune responses and induce protective immunity against toxo...

ticks are important ectoparasites which are a considerable threat to human beings and to animals all overthe world. enormous economic losses annually occur in livestock production around the world as a result oftheir existance. one of the ways to control ticks and tick-borne diseases is to introduce resistance to theseectoparasites through immunization. for identification of the putative protec...

anthrax is one of the important zoonose disease between human and cattle. bacillus anthracis is a gram- positive bacterium which its tripartite protein toxin contains protective antigen (pa), edema factor (ef) and lethal factor (lf) and a poly d- glutamic acid capsule. a recent resurgence of interest in b.anthracis resulted in improved methods for production, separation and purification of the ...

Abstract The commensal microflora collection known as microbiota has an essential role in maintaining the host's physiological homeostasis. a vital induction and regulation of local systemic immune responses. On other hand, system involves compositions. Optimal microbiota-immune cross-talk is for protective responses to pathogens tolerance self harmless environmental antigens. Any change this s...

A bacterial strain, tentatively identified as an Actinobacillus species, was found to asymptomatically colonize the pharynx of some rats and to bear cell wall antigens which cross-react with noncapsular antigens of Haemophilus influenzae type b (HIb). The cross-reacting antigens appeared to be a heterogeneous mixture with varying molecular size and charge. The antigenic moieties are probably ca...

Tuberculin skin test (TST), an age old method is based on measuring delayed-type hypersensitivity (DTH) response to purified protein derivative (PPD). However, inspite of simplicity, ease and cost effectiveness, the usefulness of PPD test is limited due to its inability to distinguish among a protective immune response, latent infection and active tuberculosis disease. On the other hand, a skin...

Abstract The development of a universal influenza vaccine to protect against variants will be the priority goal in combating virus infection. In this study, we exploited novel type protein nanoparticles consisting NP as core and NA1-M2e or NA2-M2e fusion proteins coating antigens by using an SDAD heterobifunctional crosslinker. Intramuscular immunization NP/NA-M2e (core/shell) induced increased...