There are a multiplicity of tests for liver functions, each depending upon a particular function of the liver. There has been growing recognition that the response in prothrombin time to the administration of vitamin K is of aid in the evaluation of hepatic function. The procedures heretofore employed to estimate the prothrombin response have lacked uniformity and, as a consequence, conflicting...

PURPOSE Two major functions of thrombin observed in the cornea are activation of thrombin-sensitive, proteinase-activated receptors and cleavage of fibrinogen to fibrin. The purpose of this study was to determine whether the normal human cornea itself is competent to convert prothrombin to thrombin and synthesizes the mRNA for the proteins required. METHODS Human corneas were processed for im...

A 64-year-old white male was referred for evaluation of prolonged prothrombin time (PT) and activated partial thromboplastin time (aPTT) obtained before elective surgery with initial PT and PTT results of 14.9 and 38.4 seconds, respectively, which corrected to normal in 1:1 mixes with normal plasma. Functional prothrombin assay indicated a level of 51% with thromboplastin as an activator. The p...

Purified prothrombin can be converted into thrombin in different ways (2), namely, by the use of biological activators, by the action of high concentrations of sodium citrate, and by treatment with trypsin. Biological activation of prothrombin requires lipoprotein tissue-factor(s) that have prothrombin-converting or thromboplastic activity, protein serum-factor(s) which augment thromboplastic a...

We present functional and binding data relevant to the reported roles for prothrombin and beta 2-glycoprotein I (beta 2GPI) in the expression of lupus anticoagulant activity. In a purified system containing human prothrombin, Xa, Va, and a rate-limiting concentration of phosphatidylserine (PS)/phosphatidylcholine (PC) vesicles, the preliminary incubation of vesicles with protein A separated IgG...

Hepatitis B Viral (HBV) infection is a condition of inflammation the liver. The Liver plays vital role in body which includes filtration blood, production coagulation proteins and also as storage organ. In this study, alteration some parameters include, Prothrombin time (PT), activated partial thromboplastin (APTT), Platelets counts (PLATS) were determined sixty (60) known seropositive individu...

Objectives: Congenital prothrombin (factor II) deficiency is an inherited rare bleeding disorder with autosomal recessive manner. The prevalence of this about one in 2000000 people general population, but it more common areas a high rate consanguinity. To date, there no report on the absence prothrombin, which life-threating disorder. Considering importance factor II body homeostasis, study aim...

Tests used to evaluate different aspects of hemostasis are the following: •Bleeding time: This measures the time taken for a standardized skin puncture to stop bleeding and provides an in vivo assessment of platelet response to limited vascular injury. The reference range depends on the actual method employed and varies from 2 to 9 minutes. Prolongation generally indicates a defect in platelet ...