BACKGROUND Growth factor technologies are increasingly used to enhance healing in musculoskeletal injuries, particularly in sports medicine. Two such products; platelet-rich plasma (PRP) and autologous blood, have a growing body of supporting evidence. No previous trial has directly compared the efficacy of these two methods. HYPOTHESIS Growth factor administration improves tissue regeneratio...

BACKGROUND Platelet-rich plasma (PRP) has long been known as an effective treatment in various surgical and medical fields. Face and neck revitalization with PRP is an application that is currently being explored. The aim of this paper is practical: to evaluate if there are real outcomes, benefits and side effects of a standardized injection protocol in a continuous series, without control grou...

Objective:To investigate the effect of platelet-rich plasma (PRP) injection to lower one-third anterior vaginal wall on sexual function, orgasm, in women with dysfunction by scoring FSFI. Materials and Methods:Three sessions PRP (platelet rich human autologous plasma) were administered fiftyfemale patients dysfunctiondiagnosed FSFI card obtained JAM clinic Benha city Egypt orgasmic disorder. Fe...

Introduction: Cataract is the main cause of visual impairment and vision loss in world, where 33% world's population has decreased due to cataracts. This study aims explore role platelet-rich plasma (PRP) inhibiting pro-inflammatory cytokine interleukin-1ß, thereby triggering tissue repair cataract cases vivo study.
 Methods: an experimental with a post-test-only approach control group des...

Objectives: Platelet-rich plasma (PRP) injections have recently become commercially available and are marketed directly to consumers for the treatment of knee osteoarthritis (OA). Anabolic effects from cytokines concentrated in Leukocyte-Poor configurations PRP (LP-PRP) hypothesized inhibit native catabolic environment cartilage degeneration process. Multiple Level I trials comparing LP- hyalur...

Prion diseases are infectious neurodegenerative disorders associated with the misfolded prion protein (PrP(Sc)), which appears to be the sole component of the infectious agent (termed prion). To produce disease, prions have to be absorbed into the body and reach sufficient quantities in the brain. Very little is known about the biological mechanisms controlling the initial fate of prions. Here,...

Background and purpose - In 3 papers in Acta Orthopaedica 10 years ago, we described that platelet-rich plasma (PRP) improves tendon healing in a rat Achilles transection model. Later, we found that microtrauma has similar effects, probably acting via inflammation. This raised the suspicion that the effect ascribed to growth factors within PRP could instead be due to unspecific influences on in...

BACKGROUND Administration of growth factors has been associated with increased viability of composite grafts greater than 1-cm in diameter. Platelet-rich plasma (PRP) contains many of the growth factors studied. In this study, we evaluate the effect of PRP injection on composite graft viability and the proper time for injection. METHODS A total of 24 New Zealand White rabbits were divided int...

Objective: To compare mean resting pain relief and passive external rotation improvement by Intra-articular Steroid versus intra-articular Platelet Rich Plasma injection in patients with adhesive capsulitis.
 Study Design: Prospective comparative study.
 Place Duration of Study: Armed Forces Institute Rehabilitation Medicine, Rawalpindi Pakistan, from Jan to Jun 2019.
 Methodolog...

This study evaluated the regenerative effects of platelet-rich plasma (PRP) for the degenerated intervertebral disc (IVD) in vivo. After induction of IVD degeneration in rabbits, we prepared PRP by centrifuging blood obtained from these rabbits. These PRP were injected into the nucleus pulposus (NP) of the degenerated IVDs after impregnation into gelatin hydrogel microspheres that can immobiliz...