Report of aCase |Awomanonher50spresentedwitha6-month historyofmultiple, firm, reddish, pruritic andexcoriatedpapulesandnodulesextensivelydistributedontheback (Figure 1). The patient was otherwise healthy, with a medical history of only fibromyalgia, andbothclinical examinationandbloodtest findings were unremarkable. Histologic examination of 2 punch biopsy specimens taken from the nodules on th...

Acral pseudolymphomatous angiokeratoma of children (APACHE) is a rare form of cutaneous pseudolymphoma characterized byangiomatous papules with a predilection for the acral regions of children. Classically, a dense dermal lymphocytic infiltrate composed of both T and B cells is seen in histological specimens, together with prominent vessels lined by plump endothelial cells. Increasing evidence ...

Clinical, pathological, and immunological analysis of 20 patients with ocular adnexal lymphoid disease has demonstrated several parameters which are useful for distinguishing malignant from benign lesions. Patients in the fourth or fifth decade of life presenting with an acute history of pain, oedema, epiphora, double vision, and ptosis, with a mass localised in the lacrimal gland area, are mor...

For many years, methotrexate has been used in the treatment of certain chronic medical disorders e.g. rheumatoid arthritis and psoriasis as well as a number of malignant disorders e.g. acute lymphoblastic leukemia, certain types of lymphoma and breast carcinoma. Its use has been associated with various systemic toxicities and complications. The association between methotrexate therapy and the d...

232 JEADV 2006, 20, 214–238 © 2005 European Academy of Dermatology and Venereology 3 Dargent JL, Sass U, Theunis A et al. Unusual T-cell pseudolymphoma with features of so-called pseudolymphomatous folliculitis. Dermatology 2002; 204: 159–161. 4 Baldassano MF, Bailey EM, Ferry JA et al. Cutaneous lymphoid hyperplasia and cutaneous marginal zone lymphoma: comparison of morphologic and immunophen...

We report a case of phenytoin-induced pseudolymphoma in a 28-year-old male with a history of autism and seizure disorder. The patient presented with bilateral cervical lymphadenopathy that was shown to be moderately to markedly FDG-avid on a whole body PET/CT scan. Flow cytometry analysis of peripheral blood and bone marrow mononuclear cells detected identical T cell population with aberrant im...

Lyme disease is induced by the spirochete B. burgdorferi. Spirochetes are transmitted to horses by infected ticks. Similar to humans, horses are incidental, dead-end hosts for B. burgdorferi 1. Not all infected horses develop clinical signs of Lyme disease. If clinical signs occur, they can include chronic weight loss, sporadic lameness, shifting leg lameness, low-grade fever, muscle tenderness...

We read with interest the report by Tsitsikas and colleagues about the attitudes of relatives to autopsy in a division of lymphoid malignancies. Their report shows that the attitude of the general public is positive overall and translates into high autopsy rates when the value of the examination is presented honestly and the details of the procedure are adequately explained. We would like to ad...