The anabolic action of PTH in bone is mostly mediated by cAMP/PKA and Wnt-independent activation of β-catenin/T-cell factor (TCF) signaling. β-Catenin switches the PTH receptor (PTHR) signaling from cAMP/PKA to PLC/PKC activation by binding to the PTHR. Ixazomib (Izb) was recently approved as the first orally administered proteasome inhibitor for the treatment of multiple myeloma; it acts in pa...

Renin production by the kidney is of vital importance for salt, volume, and blood pressure homeostasis. The lack human models hampers investigation into regulation renin its relevance physiology. To develop such a model, we used induced pluripotent stem cell–derived organoids to study role renin-angiotensin system in kidney. Extensive characterization revealed kidney-specific cell populations c...