Utilizing in utero aortopulmonary vascular graft placement, we developed a lamb model of congenital heart disease and increased pulmonary blood flow. We showed previously that these lambs have increased pulmonary vessel number at 4 wk of age. To determine whether this was associated with alterations in VEGF signaling, we investigated vascular changes in expression of VEGF and its receptors, Flt...

Because pulmonary arteries are end arteries, the circulation within the lung once appeared to be simple. However, an increasing amount of information concerning the systemic contribution to this circulation, mainly through bronchopulmonary anastomoses, has made the picture complex. The intricate network that the bronchial vessels establish between the aorta and the pulmonary arteries on the one...

Pulmonary embolism occurs when blood clots leave the veins where they developed, travel through the right side of the heart, and lodge in the small or large branches of the blood vessels going to the lung (pulmonary arteries). This can cause symptoms such as chest pain, difficulty breathing, or coughing up blood. In severe cases, it may result in collapse and sudden death. Long airplane flights...

Blood osmolality rises during general muscle exercise. The purpose of this work was to investigate the effect of similar slow, graded rises of blood osmolality on pulmonary vascular resistance. Hyperosmolar solutions of sodium chloride, mannitol, urea, glucose, thiourea and ethylene glycol were infused into the left lower lobe pulmonary arterial branch in the cat. Lobe blood flow, pulmonary art...

Blood osmolality rises during general muscle exercise. The purpose of this work was to investigate the effect of similar slow, graded rises of blood osmolality on pulmonary vascular resistance. Hyperosmolar solutions of sodium chloride, mannitol, urea, glucose, thiourea and ethylene glycol were infused into the left lower lobe pulmonary arterial branch in the cat. Lobe blood flow, pulmonary art...

Abnormal accumulation of connective tissue in blood vessels contributes to alterations in vascular physiology associated with disease states such as hypertension and atherosclerosis. Elastin synthesis was studied in blood vessels from newborn calves with severe pulmonary hypertension induced by alveolar hypoxia in order to investigate the cellular stimuli that elicit changes in pulmonary arteri...

Idiopathic pulmonary arterial hypertension is a progressive and potentially fatal disease with a limited number of therapeutic options. Two key lesions underlie the pathophysiology of this disease. The principal lesion is found in large- and intermediate-sized blood vessels and is characterized by medial and adventitial hypertrophy/hyperplasia, with distal extension of smooth-muscle layers into...

Vasoconstriction in response to low oxygen tension (hypoxia) in pulmonary arteries is an important physiological adaptation to reroute blood flow to areas of higher oxygenation for effective gaseous exchange. However, chronic hypoxia is a common feature of lung disease, such as chronic obstructive pulmonary disease (COPD). Hypoxic stress triggers cellular phenotypic alterations including increa...