PURPOSE To study the audiovestibular functions in cases of migraine with or without vertigo. MATERIALS AND METHODS This was a prospective study involving 50 cases of migraine who were divided into 2 groups: patients with vertigo and those without. All patients underwent a detailed otological and neurootological examination followed by full audiological and vestibular investigation including p...

It is becoming evident that oral hormonal contraceptives-besides being well established contraceptives-seem to become important medications for many functional or organic disturbances. So far, clinical effectiveness has been shown for treatment as well as prevention of menstrual bleeding disorders and menstrual-related pain symptoms. Also this is true for premenstrual syndrome (PMS) and premens...

FHM3 is a rare subtype of familial hemiplegic migraine (FHM) caused by mutations in the neuronal sodium channel gene SCN1A (1). Only five FHM3 mutations have been described in a few families since the identification of SCN1A as the third FHM gene in 2005 (1–4). In the present issue of Cephalalgia, Weller et al. (5) report the identification of two novel SCN1A FHM3 mutations in two families with...

The prevalence of migraine is higher in women than men, with female to male ratio 3:1 reproductive age. It believed that sex hormones play significant role pathogenesis. Therefore, treatment has some specificities due hormonal differences between sexes and fluctuations during menstrual cycle, pregnancy, lactation perimenopause. Treatment pregnancy depends on safety profile the therapy. NSAID-s ...

Motion sickness (MS) is an unpleasant and sometimes disabling condition in response to the perception of certain kind of motions. Its pathogenesis is incompletely understood; interactions between endocrine mechanisms and the vestibular apparatus are likely, as suggested by a higher incidence and severity of MS in females and pregnancy, the reported changes in MS susceptibility during the menstr...

Introduction Familial hemiplegic migraine (FHM) is a rare autosomal dominant subtype of migraine with aura. The FHM3 subtype is caused by mutations in SCN1A, which is also the most frequent epilepsy gene encoding the voltage-gated Na+ channel NaV1.1. The aim of this study was to explore the clinical, genetic and pathogenetic features of a pure FHM3 family. Methods A three-generation family was ...