Experimental aspect of the corrosion inhibition potential of adenine (AD), guanine (GU) and, hypoxanthine (HYP) was carried out using weight loss, potentiodynamic polarization and electrochemical impedance spectroscopy (EIS) methods while the theoretical aspect of the work was carried out by calculations of semi-empirical parameters (for AM1, MNDO, CNDO, PM3 and RM1 Hamiltonians), Fukui functio...

As a result of the investigations of Kidder and coworkers, it has recently become possible to grow the ciliated prot.oaoan Tetrahymena geleii in a culture medium which is of chemically known composition (1, 2), as well as free of other microorganisms. Interest was aroused by similarities in its requirements for amino acids (2, 3) and vitamins (4) to those of the mammal, although differences hav...

The finding that the purine portions of both adenosine triphosphate and guanosine triphosphate of the mature rabbit erythrocyte are not metabolically stable constituents of that cell, as is the heme of hemoglobin, suggested the possibility of a metabolic renewal of the nucleotides during the life of the cell (1, 2). The absence of any detectable utilization of sodium formate-Cl4 or of glycine-2...

The properties of doubly-expanded (xx-) purine analogues are compared to the natural and singly-expanded (x-) purines using quantum chemical (B3LYP, MP2) methods. Purine expansion upon incorporation of a benzene or naphthalene spacer affects the preferred orientation of the base about the glycosidic bond in the corresponding nucleoside to a similar extent. Although the natural purines preferent...

BACKGROUND/AIMS Degradation of adenine nucleotides to adenosine has been suggested to play a critical role in ischemic preconditioning (IPC). Thus, we questioned in patients undergoing partial hepatectomy whether (i) IPC will increase plasma purine catabolites and whether (ii) formation of purines in response to vascular clamping (Pringle maneuver) can be attenuated by prior IPC. METHODS 75 p...

It is known that adenosine and adenosine-5'-triphosphate (ATP) are excitatory mediators involved in carotid body (CB) hypoxic signaling. The CBs are peripheral chemoreceptors classically defined by O2, CO2, and pH sensors. When hypoxia activates the CB, it induces the release of neurotransmitters from chemoreceptor cells leading to an increase in the action potentials frequency at the carotid s...

Distribution (partition) of an organic substance between two liquid phases, usually water and an or­ ganic solvent, plays an important role in extraction, partition chromatography, and various other separa­ tion processes used in many areas of chemistry. Partition (distribution) coefficient, P, which is the quantity used to characterize the distribution of a solute between two immiscible solven...

Because of the near geometric identity of Watson-Crick (W-C) GxC and AxT base pairs, a given DNA polymerase forms the four possible correct base pairs with nearly identical catalytic efficiencies. However, human DNA polymerase iota (Pol iota), a member of the Y family of DNA polymerases, exhibits a marked template specificity, being more efficient at incorporating the correct nucleotide opposit...