Toxoplasma gondii replicates within a specialized vacuole surrounded by the parasitophorous vacuole membrane (PVM). The PVM forms intimate interactions with host mitochondria and endoplasmic reticulum (ER) in a process termed PVM-organelle association. In this study we identify a likely mediator of this process, the parasite protein ROP2. ROP2, which is localized to the PVM, is secreted from an...

Pneumonia virus of mice (PVM) has been serially propagated in a line of baby hamster kidney (BHK21) cells. A maximum titer of 6.3 x 10(6) TCID(50) per ml was obtained, and there was little variation in yield on serial passage. PVM grown in BHK21 cells was antigenically similar to virus obtained from the mouse lung, but was somewhat less virulent for the mouse after 10 serial passages in these c...

AIMS The origin of the pubovisceral muscle (PVM) from the pubic bone is known to be at elevated risk for injury during difficult vaginal births. We examined the anatomy and histology of its enthesial origin to classify its type and see if it differs from appendicular entheses. METHODS Parasagittal sections of the pubic bone, PVM enthesis, myotendinous junction, and muscle proper were harveste...

UNLABELLED The cytokine storm is an intensified, dysregulated, tissue-injurious inflammatory response driven by cytokine and immune cell components. The cytokine storm during influenza virus infection, whereby the amplified innate immune response is primarily responsible for pulmonary damage, has been well characterized. Now we describe a novel event where virus-specific T cells induce a cytoki...

This paper describes the implementation of PVM in the new WIN32-bit world. There are no restrictions to existing applications which are using PVM since it is fully compatible to the existing PVM3 release. We discuss the limits and provide some benchmarking results. The software package is freely available at netlib: http://www.netlib.org/pvm3/index.html

The Genoa Active Message Machine (GAMMA) is a lowcost cluster of Personal Computers (PCs) networked by commodity fast LAN (100base-T Ethernet) and running a Linux operating system kernel enhanced with low-latency, high throughput support to inter-process communication based on the Active Messages paradigm. The target of our work is the porting on GAMMA of a Molecular Dynamics (MD) code used to ...

This paper explores whether it is useful to view the fundamental ideas behind the smart city concept through the lens of the ‘Public Value Management’ (PVM) paradigm. It investigates how appropriate ICT investment in cities might be articulated and valued through the concept of PVM. In order to achieve this, it explores the core concepts found in the PVM literature, and draws key connections to...

The PVM system a software framework for heterogeneous concurrent computing in networked environments has evolved in the past several years into a viable technol ogy for distributed and parallel processing in a variety of disciplines PVM supports a straightforward but functionally complete message passing model and is capable of harnessing the combined resources of typically heterogeneous networ...