Prader-Willi syndrome (PWS) is a complex neurodevelopmental disorder due to errors in genomic imprinting with loss of imprinted genes that are paternally expressed from the chromosome 15q11-q13 region. Approximately 70% of individuals with PWS have a de novo deletion of the paternally derived 15q11-q13 region in which there are two subtypes (i.e., larger Type I or smaller Type II), maternal dis...

OBJECTIVE Pyungwi-san (PWS) plays a role in a number of physiologic and pharmacologic functions in many organs. Interstitial cells of Cajal (ICCs) are pacemaker cells that generate slow waves in the gastrointestinal (GI) tract. We aimed to investigate the beneficial effects of PWS in mouse small-intestinal ICCs. METHODS Enzymatic digestion was used to dissociate ICCs from the small intestine ...

Through the work of the Public Weather Service (PWS) Programme of the WMO over the years, much knowledge has been accumulated in various aspects of PWS and spread to Members through conventional training methods such as workshops, conferences, and publication of guidelines. However, some Members, particularly developing countries including Least Developed Countries, still find themselves ineffe...

Many laser wavelengths have been used in photodynamic therapy (PDT) for port wine stains (PWS). However, how these wavelengths result in different PDT outcomes has not been clearly illuminated. This study is designed to analyze which wavelengths would be the most advantageous for use in PDT for PWS. The singlet oxygen yield in PDT-treated PWS skin under different wavelengths at the same photose...

The present study was conducted to investigate the effects of crude protein (CP) content starter feed and wheat straw (WS) processing on growth performance, digestibility, ruminal fermentation, behavior Holstein calves. Sixty calves (28 male 32 female) were randomly assigned 1 4 treatments in a randomized complete block design. Treatments 2 × factorial arrangement (1) lower-CP ground mixed with...

OBJECTIVES Prader-Willi syndrome (PWS) is a genetic disorder (linked to chromosome 15q11-13) characterized by hypotonia and developmental delay, hyperphagia and obesity, hypersomnia and abnormal sleep, and behavioral problems. Such patients may also be at increased risk of obstructive sleep apnea (OSA), although whether this risk is explained by known risk factors has not previously been direct...

The Prader-Willi syndrome (PWS [MIM 17620]) and Angelman syndrome (AS [MIM 105830]) locus is controlled by a bipartite imprinting center (IC) consisting of the PWS-IC and the AS-IC. The most widely accepted model of IC function proposes that the PWS-IC activates gene expression from the paternal allele, while the AS-IC acts to epigenetically inactivate the PWS-IC on the maternal allele, thus si...

(2009). Task switching deficits and repetitive behaviour in genetic neurodevelopmental disorders: Data from children with Prader-Willi syndrome chromosome 15 q11-q13 deletion and boys with Fragile-X syndrome. ABSTRACT Prader-Willi (PWS) and Fragile-X syndromes (FraX) are associated with distinctive cognitive and behavioural profiles. We examined whether repetitive behaviours in the two syndrome...