PMCID: PMC3232567 Stenting of the aortic arch as an emergency palliation of aortic dissection after cardiac surgery in an infant M Emmel, N Sreeram, and K Brockmeier Contact information: Dr. N. Sreeram, Department Pediatric Cardiology, University Hospital of Cologne, Kerpenerstrasse 62, 50937 Cologne, Germany Phone: 0049 221 478 86301 0049 221 478 86301 Fax: 0049 221 478 86302 ; Email: N.Sreera...

This study was divided into three experiments, (a) The levels of selenium and glutathione peroxidase (GSH-PX) activity were determined for various developmental states of the mammary gland: normal (virgin, pregnant, and lactating); preneoplastic hyperplastic outgrowth lines; and neoplastic mammary tissues. Tissues from the pregnant and lactating mice had higher sele nium concentrations and GSH-...

Endophilin and Sorting Nexin 9 (Snx9) play key roles in endocytosis by membrane curvature sensing and remodeling via their Bin/Amphiphysin/Rvs (BAR) domains. BAR and the related F-BAR domains form dimeric, crescent-shaped units that occur N- or C-terminally to other lipid-binding, adaptor, or catalytic modules. In crystal structures, the PX-BAR unit of Snx9 (Snx9(PX-BAR)) adopts an overall comp...

CONTENTS PAGE Introduction 465 A definition and some general principles 468 Neuromuscular paradigms of neurotrophic competition 471 Innervation of smooth muscle 471 Innervation of skeletal muscle 472 Indirect evidence for spatial competition in skeletal muscle 473 Predictions regarding plasticity of smooth and skeletal muscle innervation 474 Competition versus co-existence of motor nerve termin...

Toward the expansion of the genetic alphabet of DNA, we present highly efficient unnatural base pair systems as an artificial third base pair for PCR. Hydrophobic unnatural base pair systems between 7-(2-thienyl)imidazo[4,5-b]pyridine (Ds) and 2-nitro-4-propynylpyrrole (Px) were fine-tuned for efficient PCR, by assessing the amplification efficiency and fidelity using different polymerases and ...

Jacobsen syndrome (JBS) is a rare congenital disorder caused by a terminal deletion of the long arm of chromosome 11. A subset of patients exhibit social behavioural problems that meet the diagnostic criteria for autism spectrum disorder (ASD); however, the underlying molecular pathogenesis remains poorly understood. PX-RICS is located in the chromosomal region commonly deleted in JBS patients ...

In the discrete case a joint probability mass function tells you the probability of any combination of events X = a and Y = b: pX ,Y (a,b) = P(X = a,Y = b) This function tells you the probability of all combinations of events (the “,” means “and”). If you want to back calculate the probability of an event only for one variable you can calculate a “marginal” from the joint probability mass funct...

|x′ = v, y′ = u 〉 = |x = u, y = v 〉 . (1) We assume a similar relationship exists in momentum space (to be completely general, we should also include a possible phase factor, but for this problem it won’t be necessary): |px = a, py = b 〉 = |px = c, py = d 〉 . (2) Because the inner product in conserved under a change of coordinates, we have: 〈x′ = u, y′ = v |px = a, py = b 〉 = 〈x = u, y = v |px ...

More than 50 human proteins with a wide range of functions have a 120 residue phosphoinositide binding module known as the PX domain. The 1.7 A X-ray crystal structure of the PX domain from the p40(phox) subunit of NADPH oxidase bound to PtdIns(3)P shows that the PX domain embraces the 3-phosphate on one side of a water-filled, positively charged pocket and reveals how 3-phosphoinositide specif...

Oxidative stress plays a key role in numerous disease processes including chronic kidney disease (CKD). In general, oxygen metabolism leads to the formation of reactive oxygen species (ROS) dangerous to cells. Although enzymes and low-molecular-weight antioxidants protect against ROS, chronic imbalances of formation and elimination can eventually overwhelm endogenous defenses leading to deleter...