One of the most important considerations in designing an integrated process for the production of organic acids is the strong pH dependence of the process parameters. The release of the acidic products during the fermentation alters the pH of the broth and subsequently affects the kinetics of cell growth and product formation. In addition, some parameters (such as the distribution coefficient o...

PURPOSE Promoter hypermethylation is an alternative pathway for gene silencing in neoplastic cells and a promising cancer detection marker. Although quantitative methylation-specific PCR (QMSP) of the GSTP1 promoter has demonstrated near perfect specificity for cancer detection in prostate biopsies, we postulated that identification and characterization of additional methylation markers might f...

Periodic intensity variations in the measured Compton profile anisotropies of ordinary ice Ih correspond to distances of 1.72 and 2.85 Å, which are close to the hydrogen bond length and the nearestneighbor O-O distance, respectively. We interpret this result as direct evidence for the substantial covalent nature of the hydrogen bond. Very good quantitative agreement between the data and a fully...

Business modeling is an important activity in software development, and the Rational Unified Process® (RUP®) provides a systematic approach to visually representing a business mode. It does not, however, provide a way to derive simulation models that support quantitative comparisons between various improvement options. Last month, in Part I of this series, we defined a Unified Modeling Language...

MOTIVATION The qualitative and quantitative characterization of protein abundance profiles over a series of time points or a set of environmental conditions is becoming increasingly important. Using isobaric mass tagging experiments, mass spectrometry-based quantitative proteomics deliver accurate peptide abundance profiles for relative quantitation. Associated data analysis workflows need to p...

ICC profiling software is widely used in the graphic arts industry. The quality of a scanner profile created by profiling software using a single training target is discussed. A more stringent quantitative analysis of the profile quality is proposed. Different targets from different photo paper manufactures are used as the testing targets to compare the quality of the profiles. A grayscale was ...

About half of the monophasic horizontal cells in carp retina receive input from both red- and green-sensitive cones. Since the horizontal cells feed back to cones, the color and feedback pathways result in wavelength- and intensity-dependent changes of the dynamics and of the receptive field amplitude profile of the horizontal cell responses. In this paper we present a quantitative model that d...

Periodic intensity variations in the measured Compton profile anisotropies of ordinary ice Ih correspond to distances of 1.8 and 3.0 Å, which are close to the hydrogen bond length and the nearest-neighbor O–O distance, respectively. We interpret this result as direct evidence for the covalent nature of the hydrogen bond. Very good quantitative agreement between the data and a fully quantum mech...

Laser Speckle Imaging (LSI) is fast, noninvasive technique to image particle dynamics in scattering media such as biological tissue. While LSI measurements are independent of the overall intensity of the laser source, we find that spatial variations in the laser source profile can impact measured flow rates. This occurs due to differences in average photon path length across the profile, and is...