نتایج جستجو برای: quinine
تعداد نتایج: 2987 فیلتر نتایج به سال:
Diastereoisomers of quinidine and quinine are used to treat arrhythmia and malaria, respectively. It has been reported that both drugs block the hERG (human ether-a-go-go-related gene) potassium channel which is essential for myocardium repolarization. Abnormality of repolarization increases risk of arrhythmia. The aim of our research is to study and compare the impacts of quinidine and quinine...
The biowaiver approach permits evaluation of bioequivalence (BE) using a set of laboratory tests, obviating the need for expensive and time-consuming pharmacokinetic BE studies provided that both the active pharmaceutical ingredient and the formulations can meet the specified criteria. In the present monograph, the biowaiver-relevant data including solubility and permeability data, therapeutic ...
The emerging resistance to quinine jeopardizes the efficacy of a drug that has been used in the treatment of malaria for several centuries. To identify factors contributing to differential quinine responses in the human malaria parasite Plasmodium falciparum, we have conducted comparative quantitative trait locus analyses on the susceptibility to quinine and also its stereoisomer quinidine, and...
OBJECTIVE To explore the cost-effectiveness of parenteral artesunate for the treatment of severe malaria in children and its potential impact on hospital budgets. METHODS The costs of inpatient care of children with severe malaria were assessed in four of the 11 sites included in the African Quinine Artesunate Malaria Treatment trial, conducted with over 5400 children. The drugs, laboratory t...
on quinine turned mostly on its piophylactic value. This was affirmed by most of the speak; but it was pointed out that the prophylacers tic exhibition of quinine could not prevent infection, though the drug was competent to destroy the plasmodium after infection had taken place. The use of the microscope in guiding and checking the employment of quinine was strongly urged. The discussion on an...
diet. Quinine injection (gr. 5) repeated. Evening temperature?99.4?F. Condition much better. One tablet of quinine bihydrochloride (gr. 5) was swallowed. Blood films?Degenerated rings ++. 18th June. Morning temperature?99?F. Evening temperature?99.6?F. Alkaline mixture two tablets of quinine bihydrochloride (gr. 10) were ordered daily. No other complications appeared and he took solid food (ric...
The rationale of this project work is to formulate oral herbal tablets of Cinchona officinalis extract containing quinine and also with pure synthetic quinine, further to determine the pharmacokinetic profile for both and compare. The concentration of quinine in the extract was estimated by HPTLC with comparison to synthetic form. Tablets were prepared from both extract and synthetic form throu...
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