Atherosclerosis, a chronic inflammatory disease of the vasculature, is the primary cause of morbidity and mortality in industrialized countries. Endothelial dysfunction/ activation is a major initiating event in atherosclerosis, which leads to the recruitment of circulating monocytes, their differentiation into macrophages, and their subsequent transformation into lipid-loaded foam cells throug...

Signaling through cAMP has been implicated in Schwann cell (SC) proliferation and myelination, but the signaling pathway components downstream of cAMP required for SC function remain unknown. Protein kinase A (PKA) is a potential downstream effector of cAMP. Here, we induced loss of Prkar1a, the gene encoding the type 1A regulatory subunit of PKA, in SC to study its role in nerve development; l...

where a = ~H/kBT, kB i~ Boltzmann's constant, T is te~­ perature, and ~ is def1ned as before. The total stat1c structure factor S(QL,QR,a) is therefore the single nilrticle structllre factor, \~eighted by th" angular dis­ tribution function, integrated over all angles: S(QL,QR,a) = Nf p(~,a) Ssp(QL,QR,~) d~ (3) Light scattering was used to determine both ~he. average length8 and magnetic moment...

OBJECTIVE GH secretagogues (GHSs) elicit a variety of biological effects in several endocrine and non-endocrine target tIssues, including activation of the hypothalamic-pituitary-adrenal axis. The latter is mainly carried out through a central hypothalamic action; yet the possibility of additional effects directly at the adrenal level cannot be ruled out. The aims of this study were to evaluate...

Svoeobrazie genofonda Russkogo Severa, davno stav nauchnym faktom, tak i ne poluchilo soderzhatel'nogo ob"yasneniya. Rezkie geneticheskie otlichiya severnyh russkih populyacij tol'ko ot yuzhnyh, no drug druga, nel'zya ob"yasnit' lish' drejfom genov. Rasshirenie spektra izuchennyh genofondov Severa ih sosedej mozhet dat' klyuch k razgadke etogo fenomena. Cel'yu raboty bylo subtotal'noe issledova...

The peculiarity of the Russian North gene pool has long become scientific fact, but yet to receive informative explanation. Genetic drift cannot be only contributing factor in striking genetic differences between not northern populations and southern ones, among individual as well. Studying pools previously underrepresented literature may help understand this phenomenon. work aimed perform a su...