In humans, the kinetics of the appearance of memory B cells and plasma cells during primary immunization are not well defined. In this study, we assessed the primary B-cell response of rabies-antigen naive volunteers during a 3-dose course of rabies vaccine compared with the B-cell response to a booster dose of rabies vaccine given to previously immunized volunteers. After a single dose of vacc...

Different approaches have been applied to develop highly attenuated rabies virus vaccines for oral vaccination of mesocarnivores. One prototype vaccine construct is SAD dIND1, which contains a deletion in the P-gene severely limiting the inhibition of type-1 interferon induction. Immunogenicity studies in foxes and skunks were undertaken to investigate whether this highly attenuated vaccine wou...

J. Arya , Y-W. Chen , K. Dewitt , Y-W. Chiang , M. R. Prausnitz 1 1 Georgia Institute of Technology, 2 Merial Ltd. Purpose To stabilize rabies DNA vaccine in a dissolving microneedle patch and evaluate immunogenicity and dose sparing in dogs. Rabies is mainly a disease of animals, whereas humans get rabies primarily when they are bitten by dogs. Vaccinating domestic dogs and other animals has r...

Introduction: Many countries endemic for the rabies virus are popular tourist destinations for travelers from developed countries. This study was designed to assess the level of awareness of rabies in a sample of travelers attending a travel medicine clinic and to assess whether the rabies-specific information provided verbally should be reinforced into a written form before th...

P reexposure rabies vaccination is recommended for individuals who are more likely to be exposed to rabies virus than the general public. 1 This vaccination series consists of 3 doses of vaccine administered IM or intradermally (ID), which permits postexposure vaccination to consist of 3 doses of vaccine rather than 5 and eliminates the need for postexposure administration of human rabies immun...

OBJECTIVE To evaluate epidemiologic features of rabies virus variants in dogs and cats in the United States during 1999 and assess the role of bat-associated variants. DESIGN Epidemiologic survey. SAMPLE POPULATION Rabies viruses from 78 dogs and 230 cats. PROCEDURE Brain specimens from rabid dogs and cats were submitted for typing of rabies virus. Historical information, including owners...

A retrospective audit was conducted of all issues of rabies vaccine or human rabies immunoglobulin (HRIG) from the Clinical Microbiology Department at University Hospital Aintree for post-exposure prophylaxis. The appropriateness of management was reviewed by a blinded panel, which used guidelines issued by the Health Protection Agency (HPA) as a standard. Thirty-six enquiries, on average 9 day...

Since 1994, several different inactivated rabies vaccines have been used to immunize domestic animals such as dogs, cats, and cattle in South Korea. The Korean Veterinary Authority has conducted safety and efficacy testes of inactivated vaccines using laboratory animals. In this study, we applied a molecular method to investigate the genetic characterization of the rabies virus (RABV) genes in ...

This study was aimed to evaluate and compare the pathogenicity of rabies virus isolated from bats and dogs, and to verify the efficacy of a commercial rabies vaccine against these isolates. For evaluation of pathogenicity, mice were inoculated by the intramuscular route (IM) with 500MICLD₅₀/0.03 mL of the viruses. The cross-protection test was performed by vaccinating groups of mice by the subc...

introduction : rabies is a disease that has been known since antiquity. it is a highly fatal acute disease of the central nervous system caused by a lyssavirus. prior to the discovery of the rabies vaccine, rabies-infected individuals fell victim to the delusions and superstitions associated with this disease. though it has been neglected in many regions of the world, rabies remains one of the ...