BACKGROUND Rad (Ras associated with diabetes) GTPase is a prototypic member of a new subfamily of Ras-related GTPases with unique structural features, although its physiological role remains largely unknown. In the present study, we characterized the Rad function in vascular smooth muscle cells (VSMCs) and the influence of adenovirus-mediated Rad (Ad-Rad) gene delivery on vascular remodeling af...

Rad is the prototypic member of a new class of Ras-related GTPases. Purification of the GTPase-activating protein (GAP) for Rad revealed nm23, a putative tumor metastasis suppressor and a development gene in Drosophila. Antibodies against nm23 depleted Rad-GAP activity from human skeletal muscle cytosol, and bacterially expressed nm23 reconstituted the activity. The GAP activity of nm23 was spe...

Using 95% limits of agreement (LOA), this study examined the reproducibility of indices of isokinetic leg strength in pubertal soccer players. Following familiarization, 23 boys performed isokinetic assessments of the knee joint muscles at 1.08, 2.16, and 4.32 rad/s during concentric exercise and at 2.16 rad/s during eccentric actions on two separate occasions. Peak torque values were recorded ...

In this paper we study G-extensions of real and complex representations of a closed normal subgroup H of a compact Lie group G when G/H is connected. The main result gives a necessary and sufficient condition for every complex irreducible H-module to extend to a G-module. In particular, we show that every complex Hmodule extends to a G-module if the fundamental group of G/H is torsion free. We ...

We prove that if u(t) is a log-log blow-up solution, of the type studied by Merle-Raphaël [14], to the L critical focusing NLS equation i∂tu+∆u+|u|u = 0 with initial data u0 ∈ H(R) in the cases d = 1, 2, then u(t) remains bounded in H away from the blow-up point. This is obtained without assuming that the initial data u0 has any regularity beyond H(R). As an application of the d = 1 result, we ...

This paper reports an in-depth case study of a rapid application development (RAD) project. RAD is a recent information systems development method noted for its high levels of user involvement and use of iterative prototyping. The paper develops a model of the core features of RAD gleaned from literature such as that published on the dynamic systems development method (DSDM). We report an ethno...

This study aimed to investigate the factor structure and external correlates of the constructs Reactive Attachment Disorder (RAD) and Disinhibited Social Engagement Disorder (DSED) from the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). The following were addressed: First, do our data support the DSM-5 conceptualization of RAD/DSED as two separate constructs? Second, are RAD and...

We are writing in response to the population and phylogenomics meeting review by Andrews & Luikart (2014) entitled 'Recent novel approaches for population genomics data analysis'. Restriction-site-associated DNA (RAD) sequencing has become a powerful and useful approach in molecular ecology, with several different published methods now available to molecular ecologists, none of which can be con...

Neural reliability and stochastic synchronization are remarkable features of real neurons with important consequences for neural computation. Both phenomena are general properties of any device with a resetting threshold, as neurons are. However, certain characteristics of the single neuron dynamics can notably improve neural reliability and stochastic synchronization. In particular, we show th...

The radius and diameter of a graph are known to satisfy the relation rad G < diam C 5 2 rad G. We show that this is the only restriction on these parameters and construl*t all nonisomorphic graphs of minimal order having a specified radius and diameter. In a graph G the diameter is diam G = ma,\_inax, d(tc, u) and the radius is rad G = min, max, d(tl, u), the min and max being taken over all po...