Hypofractionated radiation therapy has proven effective on locoregional control and tolerance in the adjuvant treatment of breast cancer. The aim of this study is to compare the results of hypofractionated radiation therapy versus conventional radiation therapy in terms of local control and tolerance. It was a retrospective study of patients observations collected from January 2007 to December ...

Radiation therapy (RT) is frequently used as part of the standard of care treatment of the majority of brain tumors. The efficacy of RT is limited by radioresistance and by normal tissue radiation tolerance. This is highlighted in pediatric brain tumors where the use of radiation is limited by the excessive toxicity to the developing brain. For these reasons, radiosensitization of tumor cells w...

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The lethal effects of ionizing radiations on cells may be either genetic or nongenetic in origin and, if genetic, may be classified as dominant or recessive. If the radiosensitivity of an organism depends on its ploidy, it may be inferred that genetic damage is involved (1). Where such a dependence has been found, the relative importance of recessive and dominant lethal effects appears to accou...

In many thoracic cancers, the radiation dose that can safely be delivered to the target volume is limited by the tolerance dose of the surrounding lung tissue. It has been hypothesized that irradiation of the heart may be an additional risk factor for the development of early radiation-induced lung morbidity. In the current study, the dependence of lung tolerance dose on heart irradiation is de...

The first study of room-temperature macromolecular crystallography data acquisition with a silicon pixel detector is presented, where the data are collected in continuous sample rotation mode, with millisecond read-out time and no read-out noise. Several successive datasets were collected sequentially from single test crystals of thaumatin and insulin. The dose rate ranged between ∼ 1320 Gy s(-...

ONJUGATION in Escherichia coli K-12 results from a sequence of consecutive steps: (1) an effective union between two cells of opposite mating types; (2) a polarized transfer of at least a portion of a male chromosome into the recipient cell, the precise order of transfer depending only on the donor strain utilized; (3) an integration of the genetic information from both parental strains into a ...

A synopsis of the available data on the radiosensitivity of female germ cells is provided, the reader being referred to recent comprehensive reviews for detailed information. The effects of ionizing radiations are considered in terms of age; germ cell stage and follicular development; type, quality, and physical factors of the exposure; and criterion chosen to assess the effect (cell killing, r...

Identification of the individual radiosensitivity of workers exposed to ionising radiation is crucial for protecting these workers from the adverse health-and-safety effects of radiation. This study aims to test and vet a new cytogenetic biomarker called G2 assay, which assesses individual radiosensitivity of healthcare personnel in medical diagnosis and treatment using ionising radiation. Anot...