The oxidative stress causes many diseases in human, therefore antioxidants have a specialposition in the medicinal chemistry. Tyrosol is an important antioxidant with a plenty ofbiological properties. There are many strategies such as clustering single drug units in orderto develop new drugs. The cluster effect can increase drug effects relative to single drug unit.Calixtyrosol is the novel clu...

The oxidative stress causes many diseases in human, therefore antioxidants have a specialposition in the medicinal chemistry. Tyrosol is an important antioxidant with a plenty ofbiological properties. There are many strategies such as clustering single drug units in orderto develop new drugs. The cluster effect can increase drug effects relative to single drug unit.Calixtyrosol is the novel clu...

background: modified radical mastectomy (mrm) is still one of globally accepted surgical techniques for breast cancer and in some selected patient is the gold standard type of surgery. the most frequent complication of this procedure is seroma under skin flaps or in the axilla as reported as much as 30% in some studies. the use of closed suction drainage system to reduce the incidence of this c...

background: primary leiomyosarcoma (lms) of the breast is a very rare neoplasm of the breast arising from the mesenchymal tissue. the clinical presentation of this entity simulates other benign and malignant lesions of mesenchymal tissue of the breast. case presentation: case 1: a 40-year-old female presented with a right-sided breast lump, which was suspected to be a malignant spindle cell tum...

the spectroscopic properties of the 2,2,6,6-tetramethyl-piperidine-1-oxyl (tempo) radicalderivatives of the fullerene (c60) were theoretically investigated. the ground state optimizedstructures of the radical adducts of the fullerene were calculated by using dft (b3lyp) with 6-31g(d) level. it was concluded that a 6-6 ring junction of c60 moiety generally covalently links to thepiperidine ring ...

the metabolic syndrome (ms) recognized as a major cause of type 2 diabetes and cardiovascular diseases, has become one of the major public health challenges worldwide. the pathogenesis of the metabolic syndrome is multiple and still poorly understood. no single factor has yet been identified as an underlying causal factor. there is a growing belief, however, that obesity, specially visceral obe...

The study of toxicities which are caused by free radical inducing chemicals (e.g., carbon tetrachloride), helps to determine the mode of action of those important drugs which act by inhibiting free radicals. Evaluation of toxicities induced by carbon tetrachloride and phenobarbitone administration was carried out in seventy healthy male rabbits. Each animal received CCI4 0.25-0.5 mL/kg bod...

the antibacterial and antioxidant activities of methanol and acetone extracts of three marine algae, including hypnea hamulosa, gracilaria corticata and enteromorpha intestinalis wereinvestigated.antioxidant activities were determined by means of total antioxidant capacity, total phenolic compounds, dpph radical scavenging activity and ferric reducing antioxidant power. antibacterial activity w...

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the current study highlights the in vitro antioxidant and antitumor activity of the previously-synthesized hydrazone derivatives against various free radicals and human cancer cell lines, respectively. the anticancer efficacies of the compound were tested by measuring cytotoxicity in cancer cell lines hela, a549, and non-cancerous nl20 cells. compounds possessing electron-donor methoxy and meth...