The study analyzed the discharge characteristics of the motor units in an intrinsic muscle of a transplanted hand. Multichannel electromyographic (EMG) recordings were obtained in 11 experimental sessions over 16 mo starting from day 205 after a hand was transplanted in a 35-yr-old man who had lost his right hand 22 yr earlier. The action potentials discharged by single motor units were identif...

Isolated newborn, but not adult, rabbit sinoatrial node (SAN) cells exhibit spontaneous activity that (unlike adult) are highly sensitive to the Na(+) current (I(Na)) blocker TTX. To investigate this TTX action on automaticity, cells were voltage clamped with ramp depolarizations mimicking the pacemaker phase of spontaneous cells (-60 to -20 mV, 35 mV/s). Ramps elicited a TTX-sensitive current ...

performed the experiments and analysed the data. 14 Y.K. designed the study and wrote the manuscript together with T. ABSTRACT 25 Spindle Ia afferents may be differentially involved in voluntary isometric contraction, depending on 26 the pattern of synaptic connections in spindle reflex pathways. We investigated how isometric 27 contraction of masseter muscles is regulated through the activity ...

We assessed the correspondence between the V-slope ventilatory threshold (VT) and the lactate threshold (LT) by using a distinctive slow submaximal ramp protocol to ensure that sufficient data points exist around the threshold. Twenty healthy young men participated. A submaximal test based on a prior maximal test (25 watt/min, medium ramp) was performed with an individual slow-ramp protocol (6-...

One of the main operational aims of the MAST experiment [1] and the proposed MAST upgrade is to investigate possible mechanisms to control the q-profile and drive off-axis current. Experiments were carried out to determine the extent to which the q-profile may be modified using two different approaches, transient and steadystate. Transient effects during the plasma current ramp-up phase were in...

PURPOSE Linac parameters potentially influencing the delivery quality of IMRT and VMAT plans are investigated with respect to threshold ranges, consequently to be considered in a linac based quality assurance procedure. Three commercially available 2D arrays are used to further investigate the influence of the measurement device. METHODS Using three commercially available 2D arrays (Mx: Matri...

Na(V)1.3 voltage-gated sodium channels have been shown to be expressed at increased levels within axotomized dorsal root ganglion neurons and within injured axons within neuromas and have been implicated in neuropathic pain. Like a number of other sodium channel isoforms, Na(V)1.3 channels produce a robust response to slow ramplike stimuli. Here we show that the response of Na(V)1.3 to ramp sti...

Transport is an inevitable process in the modern U.S. swine industry. The loading process is a novel and potentially stressful experience. This study uses behavior, heart rate and leukocyte counts to compare stress one hour before, during and after loading via ramp or elevator. Piglets were held in a home pen (control (CON)), walked up and down an aisle (handled (HAN)), or walked to a truck and...

Spindle Ia afferents may be differentially involved in voluntary isometric contraction, depending on the pattern of synaptic connections in spindle reflex pathways. We investigated how isometric contraction of masseter muscles is regulated through the activity of their muscle spindles that contain the largest number of intrafusal fibers among skeletal muscle spindles by examining the effects of...