نتایج جستجو برای: randomized cotrolled trial
تعداد نتایج: 441150 فیلتر نتایج به سال:
Effect of eye movement desensitization and reprocessing on death anxiety gastrointestinal cancer patients in Qazvin hospital 2018: A randomized clinical trial
OBJECTIVES Randomized clinical trials that enroll patients in critical or emergency care (acute care) setting are challenging because of narrow time windows for recruitment and the inability of many patients to provide informed consent. To assess the extent that recruitment challenges lead to randomized clinical trial discontinuation, we compared the discontinuation of acute care and nonacute c...
Efficient development of targeted therapies that may only benefit a fraction of patients requires clinical trial designs that use biomarkers to identify sensitive subpopulations. Various randomized phase III trial designs have been proposed for definitive evaluation of new targeted treatments and their associated biomarkers (eg, enrichment designs and biomarker-stratified designs). Before proce...
Interim analysis of a multicenter, randomized, clinical trial (Swedish Drug Elution Trial in Peripheral Arterial Disease) between November 5, 2014, and December 10, 2018. About one-half almost 2300 patients were treated with paclitaxel-coated devices uncoated devices. Approximately 25% died each group during mean follow-up 2.5 years. During the entire period, there was no significant difference...
BACKGROUND Publication bias and other reporting bias have been well documented for journal articles, but no study has evaluated the nature of results posted at ClinicalTrials.gov. We aimed to assess how many randomized controlled trials (RCTs) with results posted at ClinicalTrials.gov report statistically significant results and whether the proportion of trials with significant results differs ...
Patient relevant outcomes, measured using questionnaires, are becoming increasingly popular endpoints in randomized clinical trials (RCTs). Recently, interest in the use of item response theory (IRT) to analyze the responses to such questionnaires has increased. In this paper, we used a simulation study to examine the small sample behavior of a test statistic designed to examine the difference ...
BACKGROUND There is strong research evidence for falls prevention among older people in the community setting, although most is from Western countries. Differences between countries (eg sunlight exposure, diet, environment, exercise preferences) may influence the success of implementing falls prevention approaches in Asian countries that have been shown to be effective elsewhere in the world. T...
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